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dc.contributor.authorYilmaz, Ozlem
dc.contributor.authorMangor-Jensen, Anders
dc.contributor.authorHarboe, Torstein
dc.contributor.authorDrønen, Margareth Møgster
dc.contributor.authorMangor-Jensen, Ragnfrid
dc.contributor.authorMjaavatten, Olav
dc.contributor.authorBirkeland, Even
dc.contributor.authorSpriet, Endy
dc.contributor.authorSandven, Linda
dc.contributor.authorFurmanek, Tomasz
dc.contributor.authorBerven, Frode Steingrimsen
dc.contributor.authorWargelius, Anna
dc.contributor.authorNorberg, Birgitta
dc.date.accessioned2022-09-28T11:12:51Z
dc.date.available2022-09-28T11:12:51Z
dc.date.created2022-09-26T12:06:12Z
dc.date.issued2022
dc.identifier.citationBMC Genomics. 2022, 23 (1), .en_US
dc.identifier.issn1471-2164
dc.identifier.urihttps://hdl.handle.net/11250/3022137
dc.description.abstractTandem mass tag spectrometry (TMT labeling-LC-MS/MS) was utilized to examine the global proteomes of Atlantic halibut eggs at the 1-cell-stage post fertilization. Comparisons were made between eggs judged to be of good quality (GQ) versus poor quality (BQ) as evidenced by their subsequent rates of survival for 12 days. Altered abundance of selected proteins in BQ eggs was confirmed by parallel reaction monitoring spectrometry (PRM-LC-MS/MS). Correspondence of protein levels to expression of related gene transcripts was examined via qPCR. Potential mitochondrial differences between GQ and BQ eggs were assessed by transmission electron microscopy (TEM) and measurements of mitochondrial DNA (mtDNA) levels.en_US
dc.language.isoengen_US
dc.titleQuantitative proteome profiling reveals molecular hallmarks of egg quality in Atlantic halibut: impairments of transcription and protein folding impede protein and energy homeostasis during early developmenten_US
dc.title.alternativeQuantitative proteome profiling reveals molecular hallmarks of egg quality in Atlantic halibut: impairments of transcription and protein folding impede protein and energy homeostasis during early developmenten_US
dc.typePeer revieweden_US
dc.typeJournal articleen_US
dc.description.versionpublishedVersionen_US
dc.source.pagenumber21en_US
dc.source.volume23en_US
dc.source.journalBMC Genomicsen_US
dc.source.issue1en_US
dc.identifier.doi10.1186/s12864-022-08859-0
dc.identifier.cristin2055394
dc.relation.projectNærings- og fiskeridepartementet: 15194en_US
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1


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