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dc.contributor.authorTartor, Haitham
dc.contributor.authorKarlsen, Marius
dc.contributor.authorSkern-Mauritzen, Rasmus
dc.contributor.authorMonjane, Adérito Luis
dc.contributor.authorPress, Charles McLean
dc.contributor.authorWiik-Nielsen, Christer R.
dc.contributor.authorOlsen, Rolf Hetlelid
dc.contributor.authorLeknes, Lisa Marie
dc.contributor.authorYttredal, Karine Lindmo
dc.contributor.authorBrudeseth, Bjørn Erik
dc.contributor.authorGrove, Søren
dc.date.accessioned2022-01-21T10:12:42Z
dc.date.available2022-01-21T10:12:42Z
dc.date.created2021-12-29T11:37:29Z
dc.date.issued2021
dc.identifier.citationVaccines. 2021, 10 .en_US
dc.identifier.issn2076-393X
dc.identifier.urihttps://hdl.handle.net/11250/2838654
dc.description.abstractVaccination against salmon lice (Lepeophtheirus salmonis) is a means of control that averts the negative effects of chemical approaches. Here, we studied the immunogenicity and protective effect of a vaccine formulation (based on a salmon lice-gut recombinant protein [P33]) against Lepeophtheirus salmonis infestation in Atlantic salmon in a laboratory-based trial. Our findings revealed that P33 vaccine can provide a measure of protection against immature and adult salmon lice infestation. This protection seemed to be vaccine dose-dependent, where higher doses resulted in lower parasitic infestation rates. We also provide immunological evidence confirming that P33-specific immune response can be triggered in Atlantic salmon after P33 vaccination, and that production of P33-specific antibodies in blood can be detected in vaccinated fish. The negative correlation between P33-specific IgM in salmon plasma and salmon lice numbers on vaccinated fish suggests that protection against lice can be mediated by the specific antibody in salmon plasma. The success of P33 vaccination in protecting salmon against lice confirms the possibility of employing the hematophagous nature of the parasite to deliver salmon-specific antibodies against lice-gut proteins.en_US
dc.language.isoengen_US
dc.titleProtective Immunization of Atlantic Salmon (Salmo salarL.)against Salmon Lice (Lepeophtheirus salmonis) Infestationen_US
dc.typePeer revieweden_US
dc.typeJournal articleen_US
dc.description.versionpublishedVersionen_US
dc.source.pagenumber18en_US
dc.source.volume10en_US
dc.source.journalVaccinesen_US
dc.identifier.doi10.3390/vaccines10010016
dc.identifier.cristin1972642
dc.relation.projectNorges forskningsråd: 235477en_US
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1


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