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dc.contributor.authorGoksøyr, Siri Øfsthus
dc.contributor.authorSørensen, Helene
dc.contributor.authorGrøsvik, Bjørn Einar
dc.contributor.authorPampanin, Daniela Maria
dc.contributor.authorGoksøyr, Anders
dc.contributor.authorKarlsen, Odd André
dc.date.accessioned2022-01-06T09:41:21Z
dc.date.available2022-01-06T09:41:21Z
dc.date.created2021-12-08T14:05:38Z
dc.date.issued2021
dc.identifier.citationEnvironmental Toxicology and Pharmacology. 2021, 87:103704 1-10.en_US
dc.identifier.issn1382-6689
dc.identifier.urihttps://hdl.handle.net/11250/2836308
dc.description.abstractA luciferase reporter gene-based bioassay battery consisting of stress-activated receptors from fish, complemented with traditional fish cell-based bioassays, were used to assess the toxicity of marine sediment samples from the Byfjorden area around the city of Bergen (Norway). The reporter assays covered a wide range of cellular signalling and metabolic pathways, representing different molecular initiating events in the adverse outcome pathway framework. Cytotoxicity, generation of reactive oxygen-species, and induction of 7-ethoxyresorufin-O-deethylase activity were analysed using fish liver and gill cell lines. Chemical analyses of the sediment extracts revealed complex contamination profiles, especially at the innermost stations, which contained a wide array of persistent organic pollutants, polycyclic aromatic hydrocarbons, and metals. Sediment extracts from these sites were more potent in activating the stress-activated receptors than the other extracts, reflecting their toxicant profiles. Importantly, receptor- and cell-based bioassays complemented the chemical analyses and provided important data for future environmental risk assessments of urban marine sediments.en_US
dc.language.isoengen_US
dc.titleToxicity assessment of urban marine sediments from Western Norway using a battery of stress-activated receptors and cell-based bioassays from fishen_US
dc.typePeer revieweden_US
dc.typeJournal articleen_US
dc.description.versionpublishedVersionen_US
dc.source.pagenumber1-10en_US
dc.source.volume87:103704en_US
dc.source.journalEnvironmental Toxicology and Pharmacologyen_US
dc.identifier.doi10.1016/j.etap.2021.103704
dc.identifier.cristin1966255
dc.relation.projectNorges forskningsråd: 248840en_US
dc.relation.projectNorges forskningsråd: 244564en_US
dc.relation.projectHavforskningsinstituttet: 15445en_US
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1


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