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dc.contributor.authorHill, Jason
dc.contributor.authorEnbody, Erik D.
dc.contributor.authorPettersson, Mats E.
dc.contributor.authorSprehn, C. Grace
dc.contributor.authorBekkevold, Dorte
dc.contributor.authorFolkvord, Arild
dc.contributor.authorLaikre, Linda
dc.contributor.authorKleinau, Gunnar
dc.contributor.authorScheerer, Patrick
dc.contributor.authorAndersson, Leif
dc.date.accessioned2020-01-16T08:09:20Z
dc.date.available2020-01-16T08:09:20Z
dc.date.created2019-09-30T13:59:43Z
dc.date.issued2019
dc.identifier.citationProceedings of the National Academy of Sciences of the United States of America. 2019, 116 (37), 18473-18478.nb_NO
dc.identifier.issn0027-8424
dc.identifier.urihttp://hdl.handle.net/11250/2636545
dc.description.abstractThe evolutionary process that occurs when a species colonizes a new environment provides an opportunity to explore the mechanisms underlying genetic adaptation, which is essential knowledge for understanding evolution and the maintenance of biodiversity. Atlantic herring has an estimated total breeding stock of about 1 trillion (1012) and has colonized the brackish Baltic Sea within the last 10,000 y. Minute genetic differentiation between Atlantic and Baltic herring populations at selectively neutral loci combined with this rapid adaptation to a new environment facilitated the identification of hundreds of loci underlying ecological adaptation. A major question in the field of evolutionary biology is to what extent such an adaptive process involves selection of novel mutations with large effects or genetic changes at many loci, each with a small effect on phenotype (i.e., selection on standing genetic variation). Here we show that a missense mutation in rhodopsin (Phe261Tyr) is an adaptation to the red-shifted Baltic Sea light environment. The transition from phenylalanine to tyrosine differs only by the presence of a hydroxyl moiety in the latter, but this results in an up to 10-nm red-shifted light absorbance of the receptor. Remarkably, an examination of the rhodopsin sequences from 2,056 species of fish revealed that the same missense mutation has occurred independently and been selected for during at least 20 transitions between light environments across all fish. Our results provide a spectacular example of convergent evolution and how a single amino acid change can have a major effect on ecological adaptation.nb_NO
dc.language.isoengnb_NO
dc.titleRecurrent convergent evolution at amino acid residue 261 in fish rhodopsinnb_NO
dc.typeJournal articlenb_NO
dc.typePeer reviewednb_NO
dc.description.versionpublishedVersionnb_NO
dc.source.pagenumber18473-18478nb_NO
dc.source.volume116nb_NO
dc.source.journalProceedings of the National Academy of Sciences of the United States of Americanb_NO
dc.source.issue37nb_NO
dc.identifier.doi10.1073/pnas.1908332116
dc.identifier.cristin1731523
dc.relation.projectNorges forskningsråd: 254774nb_NO
cristin.unitcode7431,21,0,0
cristin.unitnamePelagisk fisk
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode2


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