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dc.contributor.authorMyrmel, Lene Secher
dc.contributor.authorFauske, Kristin Røen
dc.contributor.authorFjære, Even
dc.contributor.authorBernhard, Annette
dc.contributor.authorLiisberg, Ulrike
dc.contributor.authorHasselberg, Astrid Elise
dc.contributor.authorØyen, Jannike
dc.contributor.authorKristiansen, Karsten
dc.contributor.authorMadsen, Lise
dc.date.accessioned2019-08-22T11:52:12Z
dc.date.available2019-08-22T11:52:12Z
dc.date.created2019-07-30T12:05:07Z
dc.date.issued2019
dc.identifier.citationNutrients. 2019, 11:1153 (5), 1-19.nb_NO
dc.identifier.issn2072-6643
dc.identifier.urihttp://hdl.handle.net/11250/2609838
dc.description.abstractLow-fat diets and energy restriction are recommended to prevent obesity and to induce weight loss, but high-protein diets are popular alternatives. However, the importance of the protein source in obesity prevention and weight loss is unclear. The aim of this study was to investigate the ability of different animal protein sources to prevent or reverse obesity by using lean or obese C57BL/6J mice fed high-fat/high-protein or low-fat diets with casein, cod or pork as protein sources. Only the high-fat/high-protein casein-based diet completely prevented obesity development when fed to lean mice. In obese mice, ad libitum intake of a casein-based high-fat/high-protein diet modestly reduced body mass, whereas a pork-based high-fat/high-protein diet aggravated the obese state and reduced lean body mass. Caloric restriction of obese mice fed high-fat/high-protein diets reduced body weight and fat mass and improved glucose tolerance and insulin sensitivity, irrespective of the protein source. Finally, in obese mice, ad libitum intake of a low-fat diet stabilized body weight, reduced fat mass and increased lean body mass, with the highest loss of fat mass found in mice fed the casein-based diet. Combined with caloric restriction, the casein-based low-fat diet resulted in the highest loss of fat mass. Overall, the dietary protein source has greater impact in obesity prevention than obesity reversal.nb_NO
dc.language.isoengnb_NO
dc.titleThe impact of different animal-derived protein sources on adiposity and glucose homeostasis during ad libitum feeding and energy restriction in already obese micenb_NO
dc.typeJournal articlenb_NO
dc.typePeer reviewednb_NO
dc.description.versionpublishedVersionnb_NO
dc.source.pagenumber1-19nb_NO
dc.source.volume11:1153nb_NO
dc.source.journalNutrientsnb_NO
dc.source.issue5nb_NO
dc.identifier.doi10.3390/nu11051153
dc.identifier.cristin1713175
dc.relation.projectFiskeri- og havbruksnæringens forskningsfond: 900842nb_NO
dc.relation.projectEC/FP7/278373nb_NO
cristin.unitcode7431,35,0,0
cristin.unitcode7431,0,0,0
cristin.unitcode7431,34,0,0
cristin.unitnameSjømat i modellsystem
cristin.unitnameHavforskningsinstituttet
cristin.unitnameMatsikkerhet og ernæring
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1


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