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dc.contributor.authorSørhus, Elin
dc.contributor.authorIncardona, John P.
dc.contributor.authorFurmanek, Tomasz
dc.contributor.authorGoetz, Giles W.
dc.contributor.authorScholz, Nathaniel
dc.contributor.authorMeier, Sonnich
dc.contributor.authorEdvardsen, Rolf
dc.contributor.authorJentoft, Sissel
dc.date.accessioned2017-12-14T14:34:11Z
dc.date.available2017-12-14T14:34:11Z
dc.date.created2017-02-09T13:43:11Z
dc.date.issued2017
dc.identifier.citationeLIFE. 2017, 6:e20707 1-30.
dc.identifier.issn2050-084X
dc.identifier.urihttp://hdl.handle.net/11250/2471960
dc.description.abstractCrude oil spills are a worldwide ocean conservation threat. Fish are particularly vulnerable to the oiling of spawning habitats, and crude oil causes severe abnormalities in embryos and larvae. However, the underlying mechanisms for these developmental defects are not well understood. Here, we explore the transcriptional basis for four discrete crude oil injury phenotypes in the early life stages of the commercially important Atlantic haddock (Melanogrammus aeglefinus). These include defects in (1) cardiac form and function, (2) craniofacial development, (3) ionoregulation and fluid balance, and (4) cholesterol synthesis and homeostasis. Our findings suggest a key role for intracellular calcium cycling and excitation-transcription coupling in the dysregulation of heart and jaw morphogenesis. Moreover, the disruption of ionoregulatory pathways sheds new light on buoyancy control in marine fish embryos. Overall, our chemical- genetic approach identifies initiating events for distinct adverse outcome pathways and novel roles for individual genes in fundamental developmental processes.
dc.language.isoeng
dc.titleNovel adverse outcome pathways revealed by chemical genetics in a developing marine fish
dc.typePeer reviewed
dc.typeJournal article
dc.description.versionpublishedVersion
dc.source.pagenumber1-30
dc.source.volume6:e20707
dc.source.journaleLIFE
dc.identifier.doi10.7554/eLife.20707
dc.identifier.cristin1448910
dc.relation.projectNorges forskningsråd: 234367
dc.relation.projectHavforskningsinstituttet: 14236
dc.relation.projectVISTA: 6161
cristin.unitcode7431,24,0,0
cristin.unitcode7431,18,0,0
cristin.unitnameReproduksjon og utvikl.biologi
cristin.unitnameMiljøkjemi
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1


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