| dc.description.abstract | The pharmacokinetic profile of the antibacterial agent florfenicol was studied in plasma
after intravenous (i.v.) injection and in plasma, muscle and liver following oral (p.o.) administration to
cod Gadus morhua, held in seawater at 8°C and weighing 100 to 200 g. Following i.v. injection, the
plasma drug concentration-time profile showed 2 distinct phases. The plasma distribution half-life
(t1/2α) was estimated to be 1.6 h, the elimination half-life (t1/2β) to be 43 h, the total body clearance
(Cl T) to be 0.015 l kg–1 h–1 and mean residence time (MRT) to be 74 h. The volume of distribution at
steady state, Vd(ss), was calculated to be 1.1 l kg–1. Following p.o. administration, the bioavailability
was estimated to be 91%, the peak plasma concentrations (C max) to be 10.8 μg ml–1 and the time to
peak plasma concentrations (T max) to be 7 h. Corresponding C max and T max values were 13.0 μg g–1
and 9 h, respectively, in muscle and 12.1 μg g–1 and 9 h, respectively, in liver. The in vitro minimum
inhibitory concentration (MIC) values of florfenicol against 3 Vibrio anguillarum strains isolated from
diseased cod (A-21, HI-610, HI-618) were 0.5 μg ml–1 for all 3 strains. | no_NO |
