Blar i Published externally på forfatter "Wargelius, Anna"
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Approaches for delaying sexual maturation in salmon and their possible ecological and ethical implications
Iversen, Marianne; Myhr, Anne Ingeborg; Wargelius, Anna (Peer reviewed; Journal article, 2016) -
Atlantic salmon populations reveal adaptive divergence of immune related genes - A duplicated genome under selection
Kjærner-Semb, Erik Nordtorp; Ayllon, Fernando; Furmanek, Tomasz; Wennevik, Vidar; Dahle, Geir; Niemelä, Eero; Ozerov, Mikhail; Vähä, Juha-Pekka; Glover, Kevin; Rubin, Carl J.; Wargelius, Anna; Edvardsen, Rolf (Journal article, 2016) -
Autosomal sdY pseudogenes explain discordances between phenotypic sex and DNA marker for sex identification in Atlantic salmon
Ayllon, Fernando; Solberg, Monica Favnebøe; Besnier, Francois; Fjelldal, Per Gunnar; Hansen, Tom Johnny; Wargelius, Anna; Edvardsen, Rolf Brudvik; Glover, Kevin (Peer reviewed; Journal article, 2020)Despite the key role that sex-determination plays in evolutionary processes, it is still poorly understood in many species. In salmonids, which are among the best studied fishes, the master sex-determining gene sexually ... -
Collagen type XI 1 may be involved in the structural plasticity of the vertebral coulm in Atlantic salmon (Salmo salar L.)
Wargelius, Anna; Fjelldal, Per Gunnar; Nordgarden, Ulla; Grini, Ane; Krossøy, B.; Grotmol, Sindre; Totland, Geir K.; Hansen, Tom (Journal article; Peer reviewed, 2010)Atlantic salmon (Salmo salar L.) vertebral bone displays plasticity in structure, osteoid secretion and mineralization in response to photoperiod. Other properties of the vertebral bone, such as mineral content and mechanical ... -
Comparison of anadromous and landlocked Atlantic salmon genomes reveals signatures of parallel and relaxed selection across the Northern Hemisphere
Kjærner-Semb, Erik Nordtorp; Edvardsen, Rolf Brudvik; Ayllon, Fernando; Vogelsang, Petra; Furmanek, Tomasz; Rubin, Carl-Johan; Veselov, Alexey E.; Nilsen, Tom Ole; McCormick, Stephen D.; Primmer, Craig R.; Wargelius, Anna (Peer reviewed; Journal article, 2020)Most Atlantic salmon (Salmo salar L.) populations follow an anadromous life cycle, spending early life in freshwater, migrating to the sea for feeding, and returning to rivers to spawn. At the end of the last ice age ~10,000 ... -
CRISPR/Cas9-mediated ablation of elovl2 in Atlantic salmon (Salmo salar L.) inhibits elongation of polyunsaturated fatty acids and induces Srebp-1 and target genes
Winge, Per; Datsomor, Alex; Olsen, Rolf Erik; Jin, Yang; Vik, Jon Olav; Edvardsen, Rolf; Grammes, Fabian; Wargelius, Anna; Li, Keshuai (Journal article; Peer reviewed, 2019)Atlantic salmon can synthesize polyunsaturated fatty acids (PUFAs), such as eicosapentaenoic acid (20:5n-3), arachidonic acid (20:4n-6) and docosahexaenoic acid (22:6n-3) via activities of very long chain fatty acyl elongases ... -
CRISPR/Cas9-mediated editing of Δ5 and Δ6 desaturases impairs Δ8-desaturation and docosahexaenoic acid synthesis in Atlantic salmon (Salmo salar L.)
Datsomor, Alex Kojo; Olsen, Rolf Erik; Madaro, Angelico; Bones, Atle M.; Edvardsen, Rolf Brudvik; Wargelius, Anna; Winge, Per (Journal article; Peer reviewed, 2019)The in vivo functions of Atlantic salmon fatty acyl desaturases (fads2), Δ6fads2-a, Δ6fads2-b, Δ6fads2-c and Δ5fads2 in long chain polyunsaturated fatty acid (LC-PUFA) synthesis in salmon and fish in general remains to be ... -
Development of supermale and all-male Atlantic salmon to research the vgll3 allele - puberty link
Fjelldal, Per Gunnar; Hansen, Tom Johnny; Wargelius, Anna; Ayllon, Fernando; Glover, Kevin Alan; Schulz, Rüdiger W.; Fraser, Thomas (Peer reviewed; Journal article, 2020)Farmed Atlantic salmon are one of the most economically significant global aquaculture products. Early sexual maturation of farmed males represents a significant challenge to this industry and has been linked with the vgll3 ... -
Dnd knockout ablates germ cells and demonstrates germ cell independent sex differentiation in Atlantic salmon
Wargelius, Anna; Leininger, Sven Dirk; Skaftnesmo, Kai Ove; Kleppe, Lene; Andersson, Eva; Taranger, Geir Lasse; Schulz, Rüdiger W.; Edvardsen, Rolf (Journal article; Peer reviewed, 2016-02-18)Introgression of farmed salmon escapees into wild stocks is a major threat to the genetic integrity of wild populations. Using germ cell-free fish in aquaculture may mitigate this problem. Our study investigated whether ... -
Full production cycle performance of gene-edited, sterile Atlantic salmon - growth, smoltification, welfare indicators and fillet composition
Kleppe, Lene; Fjelldal, Per Gunnar; Andersson, Eva; Hansen, Tom Johnny; Sanden, Monica; Bruvik, Aina; Skaftnesmo, Kai Ove; Furmanek, Tomasz; Kjærner-Semb, Erik Nordtorp; Crespo, Diego; Flavell, Simon; Pedersen, Audun Østby; Vogelsang, Petra; Torsvik, Anja; Kvestad, Karen Anita; Olausson, Sara; Norberg, Birgitta; Schulz, Rüdiger W.; Bogerd, J.; Santi, N.; Edvardsen, Rolf Brudvik; Wargelius, Anna (Peer reviewed; Journal article, 2022)Using germ cell-free (GCF), sterile, dnd-knockout salmon for farming could solve the problems associated with precocious maturation and genetic introgression of farmed breeds into wild populations. However, prior to using ... -
Functional Annotation of All Salmonid Genomes (FAASG): an international initiative supporting future salmonid research, conservation and aquaculture
Macqueen, Daniel J.; Primmer, Craig R.; Houston, Ross D.; Nowak, Barbara F.; Bernatchez, Louis; Bergseth, Steinar; Davidson, William S.; Gallardo-Escárate, Cristian; Goldammer, Tom; Guiguen, Yann; Iturra, Patricia; Kijas, James W.; Koop, Ben F.; Lien, Sigbjørn; Maass, Alejandro; Martin, Samuel A. M.; McGinnity, Philip; Montecino, Martin; Naish, Kerry; Nichols, Krista M.; Ólafsson, Kristinn; Omholt, Stig William; Palti, Yniv; Plastow, Graham S.; Rexroad, Caird E. 3rd; Rise, Matthew L.; Ritchie, Rachael J.; Sandve, Simen Rød; Schulte, Patricia M.; Tello, Alfredo; Vidal, Rodrigo; Vik, Jon Olav; Wargelius, Anna; Yáñez, José Manuel (Peer reviewed; Journal article, 2017)We describe an emerging initiative - the ‘Functional Annotation of All Salmonid Genomes’ (FAASG), which will leverage the extensive trait diversity that has evolved since a whole genome duplication event in the salmonid ... -
Genome editing in food and feed production – implications for risk assessment
Bodin, Johanna Eva; Thorstensen, Tage; Alsheikh, Muath K; Basic, Dean; Edvardsen, Rolf Brudvik; Dalen, Knut Tomas; das Neves, Carlos Gonçalo; Duale, Nur; Eklo, Ole Martin; Ergon, Åshild Gunilla; Jevnaker, Anne-Marthe Ganes; Hindar, Kjetil; Håvarstein, Leiv Sigve; Malmstrøm, Martin; Nielsen, Kaare Magne; Olsen, Siri Lie; Rueness, Eli Knispel; Sanden, Monica; Sipinen, Ville Erling; Vikse, Rose; von Krogh, Kristine; Våge, Dag Inge; Wargelius, Anna; Wendell, Micael; Yazdankhah, Siamak Pour; Alexander, Jan; Bruzell, Ellen Merete; Hemre, Gro Ingunn; Vandvik, Vigdis; Agdestein, Angelika; Elvevoll, Edel O.; Hessen, Dag Olav; Hofshagen, Merete; Husøy, Trine; Knutsen, Helle Katrine; Krogdahl, Åshild; Nilsen, Asbjørn Magne; Rafoss, Trond; Skjerdal, Olaug Taran; Steffensen, Inger-Lise Karin; Strand, Tor Arne; Velle, Gaute; Wasteson, Yngvild (Peer reviewed; Journal article, 2021)The Norwegian Scientific Committee for Food and Environment (VKM) initiated this work to examine the extent to which organisms developed by genome-editing technologies pose new challenges in terms of risk assessment. This ... -
Genome editing in food and feed production – implications for risk assessment. Scientific Opinion of the Scientific Steering Committee of the Norwegian Scientific Committee for Food and Environment
Bodin, Johanna Eva; Thorstensen, Tage; Alsheikh, Muath K; Basic, Dean; Edvardsen, Rolf Brudvik; Dalen, Knut Tomas; Duale, Nur; Eklo, Ole Martin; Ergon, Åshild Gunilla; Jevnaker, Anne-Marthe Ganes; Hindar, Kjetil; Håvarstein, Leiv Sigve; Malmstrøm, Martin; Nielsen, Kaare Magne; Olsen, Siri Lie; Rueness, Eli Knispel; Sanden, Monica; Sipinen, Ville Erling; von Krogh, Kristine; Våge, Dag Inge; Wargelius, Anna; Wendell, Per Hans Micael; Yazdankhah, Siamak Pour; Alexander, Jan; Bruzell, Ellen Merete; Hemre, Gro Ingunn; Vandvik, Vigdis; Agdestein, Angelika; Elvevoll, Edel O.; Hessen, Dag Olav; Hofshagen, Merete; Husøy, Trine; Knutsen, Helle Katrine; Krogdahl, Åshild; Nilsen, Asbjørn Magne; Rafoss, Trond; Skjerdal, Olaug Taran; Steffensen, Inger-Lise Karin; Strand, Tor Arne; Velle, Gaute; Wasteson, Yngvild (Peer reviewed; Journal article, 2021)The Norwegian Scientific Committee for Food and Environment (VKM) initiated this work to examine the extent to which organisms developed by genome-editing technologies pose new challenges in terms of risk assessment. This ... -
Genome editing on finfish: Current status and implications for sustainability
Blix, Torill Pauline Bakkelund; Dalmo, Roy Ambli; Wargelius, Anna; Myhr, Anne Ingeborg (Peer reviewed; Journal article, 2021)Novel genome editing techniques allow for efficient and targeted improvement of aquaculture stock and might be a solution to solve challenges related to disease and environmental impacts. This review has retrieved the ... -
Indel locations are determined by template polarity in highly efficient in vivo CRISPR/Cas9- mediated HDR in Atlantic salmon
Straume, Anne Hege; Kjærner-Semb, Erik Nordtorp; Skaftnesmo, Kai Ove; guralp, hilal; Kleppe, Lene; Wargelius, Anna; Edvardsen, Rolf Brudvik (Peer reviewed; Journal article, 2020)Precise gene editing such as CRISPR/Cas9-mediated homology directed repair (HDR) can increase our understanding of gene function and improve traits of importance for aquaculture. This fine-tuned technology has not been ... -
Integrative testis transcriptome analysis reveals differentially expressed miRNAs and their mRNA targets during early puberty in Atlantic salmon
Skaftnesmo, Kai Ove; Edvardsen, Rolf; Furmanek, Tomasz; Crespo, D.; Andersson, Eva; Kleppe, Lene; Taranger, Geir Lasse; Bogerd, Jan; Schulz, Rüdiger W.; Wargelius, Anna (Peer reviewed; Journal article, 2017) -
Loss of stra8 Increases Germ Cell Apoptosis but Is Still Compatible With Sperm Production in Atlantic Salmon (Salmo salar)
Skaftnesmo, Kai Ove; Crespo, Diego; Kleppe, Lene; Andersson, Eva; Edvardsen, Rolf Brudvik; Norberg, Birgitta; Fjelldal, Per Gunnar; Hansen, Tom Johnny; Schulz, Rüdiger W.; Wargelius, Anna (Peer reviewed; Journal article, 2021)Entering meiosis strictly depends on stimulated by retinoic acid 8 (Stra8) gene function in mammals. This gene is missing in a number of fish species, including medaka and zebrafish, but is present in the majority of fishes, ... -
Maternal 3’UTRs: from egg to onset of zygotic transcription in Atlantic cod
Kleppe, Lene; Edvardsen, Rolf B.; Kuhl, Heiner; Malde, Ketil; Furmanek, Tomasz; Drivenes, Øyvind; Reinhardt, Richard; Taranger, Geir Lasse; Wargelius, Anna (Journal article; Peer reviewed, 2012-09-01)Background Zygotic transcription in fish embryos initiates around the time of gastrulation, and all prior development is initiated and controlled by maternally derived messenger RNAs. Atlantic cod egg and embryo viability ... -
Pituitary Gonadotropin Gene Expression During Induced Onset of Postsmolt Maturation in Male Atlantic Salmon: In Vivo and Tissue Culture Studies
Crespo, Diego; Skaftnesmo, Kai Ove; Kjærner-Semb, Erik Nordtorp; Yilmaz, Ozlem; Norberg, Birgitta; Olausson, Sara; Vogelsang, Petra; Bogerd, Jan; Kleppe, Lene; Edvardsen, Rolf Brudvik; Andersson, Eva; Wargelius, Anna; Hansen, Tom Johnny; Fjelldal, Per Gunnar; Schulz, Rüdiger W. (Peer reviewed; Journal article, 2022)Precocious male maturation causes reduced welfare and increased production costs in Atlantic salmon (Salmo salar) aquaculture. The pituitary produces and releases follicle-stimulating hormone (Fsh), the gonadotropin ... -
The Piwil1 N domain is required for germ cell survival in Atlantic salmon
Almeida, Fernanda Loureiro; Skaftnesmo, Kai Ove; Andersson, Eva; Kleppe, Lene; Edvardsen, Rolf Brudvik; Norberg, Birgitta; Fjelldal, Per Gunnar; Hansen, Tom Johnny; Schulz, Rüdiger W.; Wargelius, Anna (Peer reviewed; Journal article, 2022)Genetic introgression of farmed salmon into wild populations can damage the genetic integrity of wild stocks and is therefore considered as an environmental threat. One possible solution is to induce sterility in farmed ...