dc.contributor.author | Edvardsen, Rolf Brudvik | |
dc.contributor.author | Wallerman, Ola | |
dc.contributor.author | Furmanek, Tomasz | |
dc.contributor.author | Kleppe, Lene | |
dc.contributor.author | Jern, Patric | |
dc.contributor.author | Wallberg, Andreas | |
dc.contributor.author | Kjærner-Semb, Erik Nordtorp | |
dc.contributor.author | Mæhle, Stig | |
dc.contributor.author | Olausson, Sara | |
dc.contributor.author | Sundström, Elisabeth | |
dc.contributor.author | Harboe, Torstein | |
dc.contributor.author | Mangor-Jensen, Ragnfrid | |
dc.contributor.author | Drønen, Margareth Møgster | |
dc.contributor.author | Perrichon, Prescilla | |
dc.contributor.author | Norberg, Birgitta | |
dc.contributor.author | Rubin, Carl-Johan | |
dc.date.accessioned | 2023-03-07T09:18:49Z | |
dc.date.available | 2023-03-07T09:18:49Z | |
dc.date.created | 2022-05-19T09:57:02Z | |
dc.date.issued | 2022 | |
dc.identifier.citation | PLoS Genetics. 2022, 18 (2), . | en_US |
dc.identifier.issn | 1553-7390 | |
dc.identifier.uri | https://hdl.handle.net/11250/3056318 | |
dc.description.abstract | Atlantic Halibut (Hippoglossus hippoglossus) has a X/Y genetic sex determination system, but the sex determining factor is not known. We produced a high-quality genome assembly from a male and identified parts of chromosome 13 as the Y chromosome due to sequence divergence between sexes and segregation of sex genotypes in pedigrees. Linkage analysis revealed that all chromosomes exhibit heterochiasmy, i.e. male-only and female-only meiotic recombination regions (MRR/FRR). We show that FRR/MRR intervals differ in nucleotide diversity and repeat class content and that this is true also for other Pleuronectidae species. We further show that remnants of a Gypsy-like transposable element insertion on chr13 promotes early male specific expression of gonadal somatic cell derived factor (gsdf). Less than 4.5 MYA, this male-determining element evolved on an autosomal FRR segment featuring pre-existing male meiotic recombination barriers, thereby creating a Y chromosome. Our findings indicate that heterochiasmy may facilitate the evolution of genetic sex determination systems relying on linkage of sexually antagonistic loci to a sex-determining factor. | en_US |
dc.language.iso | eng | en_US |
dc.title | Heterochiasmy and the establishment of gsdf as a novel sex determining gene in Atlantic halibut | en_US |
dc.title.alternative | Heterochiasmy and the establishment of gsdf as a novel sex determining gene in Atlantic halibut | en_US |
dc.type | Peer reviewed | en_US |
dc.type | Journal article | en_US |
dc.description.version | publishedVersion | en_US |
dc.source.pagenumber | 30 | en_US |
dc.source.volume | 18 | en_US |
dc.source.journal | PLoS Genetics | en_US |
dc.source.issue | 2 | en_US |
dc.identifier.doi | 10.1371/journal.pgen.1010011 | |
dc.identifier.cristin | 2025472 | |
dc.relation.project | Norges forskningsråd: 325195 | en_US |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 2 | |