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dc.contributor.authorNedoluzhko, Artem
dc.contributor.authorMjelle, Robin
dc.contributor.authorRenström, Maria
dc.contributor.authorSkjærven, Kaja H.
dc.contributor.authorPiferrer, Francesc
dc.contributor.authorFernandes, Jorge M.O.
dc.date.accessioned2021-08-18T09:23:08Z
dc.date.available2021-08-18T09:23:08Z
dc.date.created2021-07-28T17:15:03Z
dc.date.issued2021
dc.identifier.citationGenomics. 2021, 113 (5), 3050-3057.en_US
dc.identifier.issn0888-7543
dc.identifier.urihttps://hdl.handle.net/11250/2770049
dc.description.abstractDNA methylation is one of the main epigenetic mechanisms that regulate gene expression in a manner that depends on the genomic context and varies considerably across taxa. This DNA modification was first found in nuclear genomes of eukaryote several decades ago and it has also been described in mitochondrial DNA. It has recently been shown that mitochondrial DNA is extensively methylated in mammals and other vertebrates. Our current knowledge of mitochondrial DNA methylation in fish is very limited, especially in non-model teleosts. In this study, using whole-genome bisulfite sequencing, we determined methylation patterns within non-CpG (CH) and CpG (CG) contexts in the mitochondrial genome of Nile tilapia, a non-model teleost of high economic importance. Our results demonstrate the presence of mitochondrial DNA methylation in this species predominantly within a non-CpG context, similarly to mammals. We found a strand-specific distribution of methylation, in which highly methylated cytosines were located on the minus strand. The D-loop region had the highest mean methylation level among all mitochondrial loci. Our data provide new insights into the potential role of epigenetic mechanisms in regulating metabolic flexibility of mitochondria in fish, with implications in various biological processes, such as growth and development.en_US
dc.language.isoengen_US
dc.titleThe first mitochondrial 5-methylcytosine map in a non-model teleost (Oreochromis niloticus) reveals extensive strand-specific and non-CpG methylationen_US
dc.typePeer revieweden_US
dc.typeJournal articleen_US
dc.description.versionpublishedVersionen_US
dc.source.pagenumber3050-3057en_US
dc.source.volume113en_US
dc.source.journalGenomicsen_US
dc.source.issue5en_US
dc.identifier.doi10.1016/j.ygeno.2021.07.007
dc.identifier.cristin1922906
dc.relation.projectEC/H2020/683210en_US
dc.relation.projectNorges forskningsråd: 250548en_US
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1


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