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dc.contributor.authorBernhoft, Aksel
dc.contributor.authorHøgåsen, Helga Rachel
dc.contributor.authorRosenlund, Grethe
dc.contributor.authorMoldal, Torfinn
dc.contributor.authorGrove, Søren
dc.contributor.authorBerntssen, Marc
dc.contributor.authorThoresen, Stein Istre
dc.contributor.authorAlexander, Jan
dc.date.accessioned2018-10-31T15:21:42Z
dc.date.available2018-10-31T15:21:42Z
dc.date.created2018-10-14T12:17:37Z
dc.date.issued2018
dc.identifier.citationFood and Chemical Toxicology. 2018, 121 374-386.nb_NO
dc.identifier.issn0278-6915
dc.identifier.urihttp://hdl.handle.net/11250/2570469
dc.description.abstractPost-smolt Atlantic salmon (Salmo salar) were fed with standard feed added one of five concentrations of either pure deoxynivalenol (DON; 0.5–6 mg/kg) or pure ochratoxin A (OTA; 0.2–2.4 mg/kg), or no added toxins for up to 8 weeks. Performance effects (feed intake, feed efficiency, gain, length and condition factor), various clinical biochemical parameters, packed cell volume and vaccination response against Aeromonas salmonicidae were all inversely correlated with DON dose, whereas relative liver weight increased with DON dose. In fish fed OTA, however, the effects at the doses tested were rather small. We observed no effects of OTA exposure on performance parameters, but some clinical biochemical parameters tended to increase with OTA dose primarily at 3 weeks, and compared with controls OTA exposure caused increased mRNA expression of two immune markers in the spleen. No liver histopathological effects were found from DON or OTA exposure. For DON, we derived a BMDL20 of 0.3 mg/kg feed for reduced total protein in plasma, a BMDL5 of 0.5 mg/kg feed for reduced condition factor, and a NOAEL of 1 mg/kg feed for DON. For OTA, a BMDL or NOAEL could not be derived (>2.4 mg/kg).nb_NO
dc.language.isoengnb_NO
dc.titleEffects of dietary deoxynivalenol or ochratoxin A on performance and selected health indices in Atlantic salmon (Salmo salar)nb_NO
dc.title.alternativeEffects of dietary deoxynivalenol or ochratoxin A on performance and selected health indices in Atlantic salmon (Salmo salar)nb_NO
dc.typeJournal articlenb_NO
dc.typePeer reviewednb_NO
dc.description.versionpublishedVersionnb_NO
dc.source.pagenumber374-386nb_NO
dc.source.volume121nb_NO
dc.source.journalFood and Chemical Toxicologynb_NO
dc.identifier.doi10.1016/j.fct.2018.08.079
dc.identifier.cristin1620215
dc.relation.projectNorges forskningsråd: 199626nb_NO
cristin.unitcode7431,32,0,0
cristin.unitnameTrygt fôr
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1


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