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dc.contributor.authorWik, Maria
dc.contributor.authorDahl, Lisbeth
dc.contributor.authorMoe, Vibeke
dc.contributor.authorAbel, Marianne Hope
dc.contributor.authorBrantsæter, Anne Lise
dc.contributor.authorØyen, Jannike
dc.contributor.authorMeltzer, Helle Margrete
dc.contributor.authorStormark, Kjell Morten
dc.contributor.authorGraff, Ingvild Eide
dc.contributor.authorSmith, Lars
dc.contributor.authorKjellevold, Marian
dc.date.accessioned2018-09-20T12:50:19Z
dc.date.available2018-09-20T12:50:19Z
dc.date.created2018-09-18T11:18:26Z
dc.date.issued2018
dc.identifier.citationNutrients. 2018, 10 .nb_NO
dc.identifier.issn2072-6643
dc.identifier.urihttp://hdl.handle.net/11250/2563700
dc.description.abstractInadequate iodine status affects the synthesis of the thyroid hormones and may impair brain development in fetal life. The aim of this study was to explore the association between maternal iodine status in pregnancy measured by urinary iodine concentration (UIC) and child neurodevelopment at age 6, 12 and 18 months in a population-based cohort. In total, 1036 families from nine locations in Norway were enrolled in the little in Norway cohort. The present study includes n = 851 mother-child pairs with singleton pregnancies, no use of thyroid medication in pregnancy, no severe genetic disorder, data on exposure (UIC) in pregnancy and developmental outcomes (Bayley Scales of Infant and Toddler Development, third edition). Data collection also included general information from questionnaires. We examined associations between UIC (and use of iodine-containing supplements) and repeated measures of developmental outcomes using multivariable mixed models. The median UIC in pregnancy was 78 µg/L (IQR 46–130), classified as insufficient iodine intake according to the WHO. Eighteen percent reported use of iodine-containing multisupplements. A UIC below ~100 was associated with reduced receptive (p = 0.025) and expressive language skills (p = 0.002), but not with reduced cognitive or fine- and gross motor skills. Maternal use of iodine-containing supplements was associated with lower gross motor skills (b = −0.18, 95% CI = −0.33, −0.03, p = 0.02), but not with the other outcome measures. In conclusion, an insufficient iodine intake in pregnancy, reflected in a UIC below ~100 µg/L, was associated with lower infant language skills up to 18 months. The use of iodine-containing supplements was not associated with beneficial effects.nb_NO
dc.language.isoengnb_NO
dc.relation.urihttp://www.mdpi.com/2072-6643/10/9/1270
dc.titleMaternal Iodine Status is Associated with Offspring Language Skills in Infancy and Toddlerhoodnb_NO
dc.title.alternativeMaternal Iodine Status is Associated with Offspring Language Skills in Infancy and Toddlerhoodnb_NO
dc.typeJournal articlenb_NO
dc.typePeer reviewednb_NO
dc.description.versionpublishedVersionnb_NO
dc.source.pagenumber13nb_NO
dc.source.volume10nb_NO
dc.source.journalNutrientsnb_NO
dc.identifier.doi10.3390/nu10091270
dc.identifier.cristin1610513
cristin.unitcode7431,34,0,0
cristin.unitcode7431,35,0,0
cristin.unitcode7431,0,0,0
cristin.unitnameMatsikkerhet og ernæring
cristin.unitnameSjømat i modellsystem
cristin.unitnameHavforskningsinstituttet
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1


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