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dc.contributor.authorNøstbakken, Ole Jakob
dc.contributor.authorDuinker, Arne
dc.contributor.authorRasinger, Josef Daniel
dc.contributor.authorNilsen, Bente Merete
dc.contributor.authorSanden, Monica
dc.contributor.authorFrantzen, Sylvia
dc.contributor.authorHove, Helge Torbjørn
dc.contributor.authorLundebye, Anne-Katrine
dc.contributor.authorBerntssen, Marc
dc.contributor.authorHannisdal, Rita
dc.contributor.authorMadsen, Lise
dc.contributor.authorMåge, Amund
dc.date.accessioned2018-09-10T09:18:27Z
dc.date.available2018-09-10T09:18:27Z
dc.date.created2018-08-31T15:54:25Z
dc.date.issued2018
dc.identifier.citationEnvironment International. 2018, 119 544-557.nb_NO
dc.identifier.issn0160-4120
dc.identifier.urihttp://hdl.handle.net/11250/2561682
dc.description.abstractBrominated flame-retardants (BFRs) such as polybrominated diphenyl ethers (PBDE) and hexabromocyclododecane (HBCD) are considered hazardous to human health. Due to their persistence, they are still present in the environment and in biota and seafood is major contributor of BFRs to human exposure. Here, we used data from >9700 samples of wild and farmed fish, fish feed and fish feed ingredients collected from the North Atlantic between 2006 and 2016 aiming to investigate factors influencing the risk assessments of BFRs. Due to most representative number of analyses, PBDEs were the main focus of investigation. Mean ∑PBDE in fillet samples ranged from below quantification in Atlantic cod fillet to 2.0 μg kg−1 in Atlantic halibut. The main congener contributing to the ∑PBDE in all species was BDE 47. Factors affecting the level of BFR in seafood were multifaceted, and the levels were within species mainly determined by fish age, geographical origin and time of sampling. BDE 47, 99, 153 and HBCD were selected for margin of exposure (MOE) evaluation. When other sources of BFR than seafood were excluded, our risk assessment showed low risk at the current dietary intake of seafood. However, the dietary intake of BDE 99 may be of concern for toddlers when all sources are considered. The choice of fish species, dietary studies, choice of statistics, as well as exposure from other sources than seafood, were all factors that influenced the final MOE of BFRs. We propose the use of regression on order statistics as a tool for risk assessment, to illustrate means and spreads in large surveillance datasets to avoid the issue of measurements below the limit of quantification. A harmonized, updated evaluation of the risk associated with exposure to BFRs from diet, air and dust is warranted, where the fish species most commonly consumed also is taken into consideration.nb_NO
dc.language.isoengnb_NO
dc.titleFactors influencing risk assessments of brominated flame-retardants; evidence based on seafood from the North East Atlantic Oceannb_NO
dc.title.alternativeFactors influencing risk assessments of brominated flame-retardants; evidence based on seafood from the North East Atlantic Oceannb_NO
dc.typeJournal articlenb_NO
dc.typePeer reviewednb_NO
dc.description.versionpublishedVersionnb_NO
dc.source.pagenumber544-557nb_NO
dc.source.volume119nb_NO
dc.source.journalEnvironment Internationalnb_NO
dc.identifier.doi10.1016/j.envint.2018.04.044
dc.identifier.cristin1605937
dc.relation.projectFiskeri- og havbruksnæringens forskningsfond: 900112nb_NO
dc.relation.projectFiskeri- og havbruksnæringens forskningsfond: 232104nb_NO
dc.relation.projectFiskeri- og havbruksnæringens forskningsfond: 232094nb_NO
cristin.unitcode7431,35,0,0
cristin.unitcode7431,33,0,0
cristin.unitcode7431,32,0,0
cristin.unitnameSjømat i modellsystem
cristin.unitnameFremmed- og smittestoff
cristin.unitnameTrygt fôr
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1


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