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dc.contributor.authorSørhus, Elin
dc.contributor.authorIncardona, John P.
dc.contributor.authorKarlsen, Ørjan
dc.contributor.authorLinbo, Tiffany
dc.contributor.authorSørensen, Lisbet
dc.contributor.authorNordtug, Trond
dc.contributor.authorvan der Meeren, Terje
dc.contributor.authorThorsen, Anders
dc.contributor.authorThorbjørnsen, Maja
dc.contributor.authorJentoft, Sissel
dc.contributor.authorEdvardsen, Rolf
dc.contributor.authorMeier, Sonnich
dc.date.accessioned2016-08-24T12:09:46Z
dc.date.accessioned2016-09-15T10:40:50Z
dc.date.available2016-08-24T12:09:46Z
dc.date.available2016-09-15T10:40:50Z
dc.date.issued2016-08-10
dc.identifier.citationSørhus E, Incardona JP, Karlsen Ø, Linbo T, Sørensen L, Nordtug T, van der Meeren T, Thorsen A, Thorbjørnsen M, Jentoft S, Edvardsen RB, Meier S (2016) Crude oil exposures reveal roles for intracellular calcium cycling in haddock craniofacial and cardiac development. Scientific Reports 6:31058nb_NO
dc.identifier.issn2045-2322
dc.identifier.urihttp://hdl.handle.net/11250/2407483
dc.description-nb_NO
dc.description.abstractRecent studies have shown that crude oil exposure affects cardiac development in fish by disrupting excitation-contraction (EC) coupling. We previously found that eggs of Atlantic haddock (Melanogrammus aeglefinus) bind dispersed oil droplets, potentially leading to more profound toxic effects from uptake of polycyclic aromatic hydrocarbons (PAHs). Using lower concentrations of dispersed crude oil (0.7–7 μg/L ∑PAH), here we exposed a broader range of developmental stages over both short and prolonged durations. We quantified effects on cardiac function and morphogenesis, characterized novel craniofacial defects, and examined the expression of genes encoding potential targets underlying cardiac and craniofacial defects. Because of oil droplet binding, a 24-hr exposure was sufficient to create severe cardiac and craniofacial abnormalities. The specific nature of the craniofacial abnormalities suggests that crude oil may target common craniofacial and cardiac precursor cells either directly or indirectly by affecting ion channels and intracellular calcium in particular. Furthermore, down-regulation of genes encoding specific components of the EC coupling machinery suggests that crude oil disrupts excitation-transcription coupling or normal feedback regulation of ion channels blocked by PAHs. These data support a unifying hypothesis whereby depletion of intracellular calcium pools by crude oil-derived PAHs disrupts several pathways critical for organogenesis in fish.nb_NO
dc.language.isoengnb_NO
dc.publisherNature Publishing Groupnb_NO
dc.rightsNavngivelse-DelPåSammeVilkår 3.0 Norge*
dc.rights.urihttp://creativecommons.org/licenses/by-sa/3.0/no/*
dc.titleCrude oil exposures reveal roles for intracellular calcium cycling in haddock craniofacial and cardiac developmentnb_NO
dc.typeJournal articlenb_NO
dc.typePeer reviewednb_NO
dc.date.updated2016-08-24T12:09:46Z
dc.subject.nsiVDP::Matematikk og naturvitenskap: 400::Zoologiske og botaniske fag: 480::Marinbiologi: 497nb_NO
dc.subject.nsiVDP::Mathematics and natural scienses: 400::Zoology and botany: 480::Marine biology: 497nb_NO
dc.subject.nsiVDP::Matematikk og naturvitenskap: 400::Kjemi: 440::Miljøkjemi, naturmiljøkjemi: 446nb_NO
dc.subject.nsiVDP::Mathematics and natural scienses: 400::Chemistry: 440::Environmental chemistry, natural environmental chemistry: 446nb_NO
dc.identifier.doi10.1038/srep31058
dc.identifier.cristin1371929
dc.relation.projectNorges forskningsråd: 234367nb_NO


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