Browsing Brage IMR by Author "Skjærven, Kaja Helvik"
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Associations Between Behavioral Effects of Bisphenol A and DNA Methylation in Zebrafish Embryos
Olsvik, Pål Asgeir; Whatmore, Paul; Penglase, Samuel; Skjærven, Kaja Helvik; Anglès d'Auriac, Marc; Ellingsen, Ståle (Peer reviewed; Journal article, 2019)Endocrine-disrupting contaminants have been associated with aberrant changes in epigenetic pathways in animals. In this study, zebrafish embryos were exposed bisphenol A (BPA) to search for associations between behavior ... -
Comparative analysis of genome-scale, base-resolution DNA methylation profiles across 580 animal species
Klughammer, Johanna; Romanovskaia, Daria; Nemc, Amelie; Posautz, Annika; Seid, Charlotte A.; Schuster, Linda C.; Keinath, Melissa C.; Lugo Ramos, Juan Sebastian; Kosack, Lindsay; Evankow, Ann; Printz, Dieter; Kirchberger, Stefanie; Ergüner, Bekir; Datlinger, Paul; Fortelny, Nikolaus; Schmidl, Christian; Farlik, Matthias; Skjærven, Kaja Helvik; Bergthaler, Andreas; Liedvogel, Miriam; Thaller, Denise; Burger, Pamela A.; Hermann, Marcela; Distel, Martin; Distel, Daniel L.; Kübber-Heiss, Anna; Bock, Christoph (Peer reviewed; Journal article, 2023)Methylation of cytosines is a prototypic epigenetic modification of the DNA. It has been implicated in various regulatory mechanisms across the animal kingdom and particularly in vertebrates. We mapped DNA methylation in ... -
Dietary electrolyte balance of Atlantic salmon (Salmo salar) freshwater feeds: Impact on osmoregulation, mineral metabolism and performance in seawater
Prabhu, P. Antony Jesu; Fjelldal, Per Gunnar; Remø, Sofie C.; Selvam, Chandrasekar; Hamre, Kristin; Espe, Marit; Holen, Elisabeth; Skjærven, Kaja Helvik; Vikså, Vibeke; Subramanian, Saravanan; Schrama, Johan W.; Sissener, Nini (Peer reviewed; Journal article, 2022)Dietary electrolyte balance is the equilibrium of monovalent cations and anions that influence the acid-base balance of the feed (dEB = Na + K − Cl, mEq kg−1). Dietary electrolytes/minerals can influence the physiological ... -
Earlier or delayed seasonal broodstock spawning changes nutritional status and metabolic programming of growth for next-generation Atlantic salmon
Skjærven, Kaja Helvik; Mommens, Maren; Adam, Anne-Catrin; Saito, Takaya; Oveland, Eystein; Espe, Marit (Peer reviewed; Journal article, 2022)Atlantic salmon (Salmo salar) breeding companies depend on changing light, temperature and feeding regimes to achieve new generations outside the natural spawning season. However, there have been few conducted trials ... -
The first mitochondrial 5-methylcytosine map in a non-model teleost (Oreochromis niloticus) reveals extensive strand-specific and non-CpG methylation
Nedoluzhko, Artem; Mjelle, Robin; Renström, Maria; Skjærven, Kaja Helvik; Piferrer, Francesc; Fernandes, Jorge Manuel de Oliveira (Peer reviewed; Journal article, 2021)DNA methylation is one of the main epigenetic mechanisms that regulate gene expression in a manner that depends on the genomic context and varies considerably across taxa. This DNA modification was first found in nuclear ... -
Kysttorsken vår er sterkt truet
Skjærven, Kaja Helvik (Others, 2012) -
Long-term effect of parental selenium supplementation on the one-carbon metabolism in rainbow trout (Oncorhynchus mykiss) fry exposed to hypoxic stress
Wischhusen, Pauline; Heraud, Cécile; Skjærven, Kaja Helvik; Kaushik, Sadasivam J.; Fauconneau, Benoit; Prabhu, P. Antony Jesu; Fontagné-Dicharry, Stéphanie (Peer reviewed; Journal article, 2022)This study evaluated how different forms of selenium (Se) supplementation into rainbow trout broodstock diets modified the one-carbon metabolism of the progeny after the beginning of exogenous feeding and followed by hypoxia ... -
Metabolic and molecular signatures of improved growth in Atlantic salmon (Salmo salar) fed surplus levels of methionine, folic acid, vitamin B6 and B12 throughout smoltification.
Adam, Anne-Catrin; Saito, Takaya; Espe, Marit; Whatmore, Paul; Fernandes, Jorge Manuel de Oliveira; Vikeså, Vibeke; Skjærven, Kaja Helvik (Peer reviewed; Journal article, 2021)A moderate surplus of the 1C nutrients methionine, folic acid, vitamin B6 and B12 above dietary recommendations for Atlantic salmon has shown to improve growth and reduce hepatosomatic index in the on-growing salt water ... -
Methionine: An Indispensable Amino Acid in Cellular Metabolism and Health of Atlantic Salmon
Espe, Marit; Adam, Anne-Catrin; Saito, Takaya; Skjærven, Kaja Helvik (Peer reviewed; Journal article, 2023)Methionine is an indispensable amino acid with an important role as the main methyl donor in cellular metabolism for both fish and mammals. Metabolization of methionine to the methyl donor S-adenosylmethionine (SAM) has ... -
Micronutrient supplementation affects DNA methylation in male gonads with potential intergenerational epigenetic inheritance involving the embryonic development through glutamate receptor-associated genes
Saito, Takaya; Whatmore, Paul; Taylor, John F.; Fernandes, Jorge Manuel de Oliveira; Adam, Anne-Catrin; Tocher, Douglas R.; Espe, Marit; Skjærven, Kaja Helvik (Peer reviewed; Journal article, 2022)DNA methylation has an important role in intergenerational inheritance. An increasing number of studies have reported evidence of germline inheritance of DNA methylation induced by nutritional signals in mammals. Vitamins ... -
Micronutrient supplementation affects transcriptional and epigenetic regulation of lipid metabolism in a dose-dependent manner
Saito, Takaya; Whatmore, Paul; Taylor, John F.; Fernandes, Jorge Manuel de Oliveira; Adam, Anne-Catrin; Tocher, Douglas R.; Espe, Marit; Skjærven, Kaja Helvik (Peer reviewed; Journal article, 2020) -
Out-of-season spawning affects the nutritional status and gene expression in both Atlantic salmon female broodstock and their offspring
Skjærven, Kaja Helvik; Oveland, Eystein; Mommens, Maren; Samori, Elsa; Saito, Takaya; Adam, Anne-Catrin; Espe, Marit (Peer reviewed; Journal article, 2020)The Atlantic salmon aquaculture industry relies on adjustments of female broodstock spawning season to meet the demand for delivery of embryos outside the natural spawning season. Earlier results from zebrafish have shown ... -
Parental high dietary arachidonic acid levels modulated the hepatic transcriptome of adult zebrafish (Danio rerio) progeny
Adam, Anne-Catrin; Skjærven, Kaja Helvik; Whatmore, Paul; Moren, Mari; Lie, Kai Kristoffer (Journal article; Peer reviewed, 2018)Disproportionate high intake of n-6 polyunsaturated fatty acids (PUFAs) in the diet is considered as a major human health concern. The present study examines changes in the hepatic gene expression pattern of adult male ... -
Parental micronutrient deficiency distorts liver DNA methylation and expression of lipid genes associated with a fatty-liver-like phenotype in offspring
Skjærven, Kaja Helvik; Jakt, Lars Martin; Fernandes, Jorge Manuel de Oliveira; Dahl, John Arne; Adam, Anne-Catrin; Klughammer, Johanna; Bock, Christoph; Espe, Marit (Journal article; Peer reviewed, 2018)Micronutrient status of parents can affect long term health of their progeny. Around 2 billion humans are affected by chronic micronutrient deficiency. In this study we use zebrafish as a model system to examine morphological, ... -
Parental selenium nutrition affects the one-carbon metabolism and the hepatic dna methylation pattern of rainbow trout (Oncorhynchus mykiss) in the progeny
Wischhusen, Pauline; Saito, Takaya; Heraud, Cécile; Kaushik, Sadasivam J.; Fauconneau, Benoit; Prabhu, P. Antony Jesu; Fontagné-Dicharry, Stéphanie; Skjærven, Kaja Helvik (Peer reviewed; Journal article, 2020)Selenium is an essential micronutrient and its metabolism is closely linked to the methionine cycle and transsulfuration pathway. The present study evaluated the effect of two different selenium supplements in the diet of ... -
Profiling DNA methylation patterns of zebrafish liver associated with parental high dietary arachidonic acid.
Adam, Anne-Catrin; Lie, Kai Kristoffer; Whatmore, Paul; Jakt, Lars Martin; Moren, Mari; Skjærven, Kaja Helvik (Journal article; Peer reviewed, 2019)Diet has been shown to influence epigenetic key players, such as DNA methylation, which can regulate the gene expression potential in both parents and offspring. Diets enriched in omega-6 and deficient in omega-3 PUFAs ... -
Program for overvåking av fiskefôr - Årsrapport for prøver innsamlet i 2022
Sele, Veronika; Silva, Marta Sofia; Prabhu, P. Antony Jesu; Hamre, Kristin; Skjærven, Kaja Helvik; Espe, Marit; Liland, Nina Sylvia; Lie, Kai Kristoffer; Berntssen, Marc HG; Lundebye, Anne-Katrine (Rapport fra havforskningen;2023 - 36, Research report, 2023)Overvåknings- og kartleggingsprogrammet for fiskefôr utføres på vegne av Mattilsynet. I 2022 fikk Havforskningsinstituttet tilsendt 80 fiskefôr, 13 fiskemel, 2 fiskeproteinkonsentrat, 15 vegetabilske mel, 3 insektmel, 10 ... -
Risk assessment of Aquaterra® oil for its intended use as ingredient in fish feed
Thorstensen, Tage; Bodin, Johanna Eva; Duale, Nur; Jevnaker, Anne-Marthe Ganes; Johansen, Johan; Sipinen, Ville Erling; Shapaval, Volha; Øystein, Sæle; Prydz, Kristian; Skjærven, Kaja Helvik (Peer reviewed; Journal article, 2023)The Norwegian Scientific Committee for food an Environment (VKM) has assessed an application for authorisation of refined oilseed rape oil (Aquaterra®) derived from genetically modified oilseed rape line NS-B50027-4 for ... -
Risk assessment of Aquaterra® oil for its intended use as ingredient in fish feed. Scientific Opinion of the Norwegian Scientific Committee for Food and Environment
Thorstensen, Tage; Bodin, Johanna Eva; Duale, Nur; Jevnaker, Anne-Marthe Ganes; Johansen, Johan; Sipinen, Ville Erling; Shapaval, Volha; Sæle, Øystein; Prydz, Kristian; Skjærven, Kaja Helvik (Peer reviewed; Journal article, 2023)The Norwegian Scientific Committee for food an Environment (VKM) has assessed an application for authorisation of refined oilseed rape oil (Aquaterra®) derived from genetically modified oilseed rape line NS-B50027-4 for ... -
Spawning manipulation, broodfish diet feeding and egg production in farmed Atlantic salmon
Fjelldal, Per Gunnar; Adam, Anne-Catrin; Berge, Gerd Marit; Lein, Ingrid; Hevrøy, Ernst Morten; Næve, Ingun; Seim, Rudi R.; Mommens, Maren; Skjærven, Kaja Helvik; Hansen, Tom Johnny; Hamre, Kristin (Peer reviewed; Journal article, 2024)Atlantic salmon aquaculture relies on continuous supply of high quality eggs. Broodfish nutrition and manipulation of ovulation time (photoperiod and temperature) are key factors. The optimum feeding period with broodfish ...