Browsing Brage IMR by Author "Olsvik, Pål Asgeir"
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Associations Between Behavioral Effects of Bisphenol A and DNA Methylation in Zebrafish Embryos
Olsvik, Pål Asgeir; Whatmore, Paul; Penglase, Samuel; Skjærven, Kaja Helvik; Anglès d'Auriac, Marc; Ellingsen, Ståle (Peer reviewed; Journal article, 2019)Endocrine-disrupting contaminants have been associated with aberrant changes in epigenetic pathways in animals. In this study, zebrafish embryos were exposed bisphenol A (BPA) to search for associations between behavior ... -
Benzo(a)pyrene reduces osteoclast and osteoblast activity in ex-vivo scales of zebrafish (Danio rerio [Hamilton-Buchanan, 1822]) and goldfish (Carassius auratus [Linnaeus, 1758])
Torvanger, Ivar; Metz, J. R.; Olsvik, Pål Asgeir; Søfteland, Liv Ingeborg Rosvoll; Lie, Kai Kristoffer (Journal article; Peer reviewed, 2018)Environmental contaminants have previously been demonstrated to cause bone deformities mediated through the aryl hydrocarbon receptor (AhR) in fish and mammals. Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous in the ... -
Bioaccumulation of mercury and transcriptional responses in tusk (Brosme brosme), a deep-water fish from a Norwegian fjord
Olsvik, Pål Asgeir; Mahjour Azad, Atabak; Yadetie, Fekadu (Peer reviewed; Journal article, 2021)High concentrations of mercury (Hg) have been documented in deep-water fish species from some Norwegian fjords. In this study, tusk (Brosme brosme) was sampled from four locations in the innermost parts of Sognefjorden in ... -
Chlorpyrifos-induced dysfunction of lipid metabolism is not restored by supplementation of polyunsaturated fatty acids EPA and ARA in Atlantic salmon liver cells
Olsvik, Pål Asgeir; Hammer, SK; Sanden, Monica; Søfteland, Liv Ingeborg Rosvoll (Journal article; Peer reviewed, 2019)Exposure to contaminants can lead to accumulation of lipids in the liver. This study aimed to examine whether eicosapentaenoic acid (EPA) and arachidonic acid (ARA) supplementation can protect fish cells against the negative ... -
Comparing novel shotgun DNA sequencing and state-of-the-art proteomics approaches for authentication of fish species in mixed samples
Varunjikar, Madhushri S.; Moreno-Ibarguen, Carlos; Andrade-Martinez, Juan S.; Tung, Hui-Shan; Belghit, Ikram; Palmblad, Magnus; Olsvik, Pål Asgeir; Reyes, Alejandro; Rasinger, Josef; Lie, Kai Kristoffer (Others, 2021)Replacement of high-value fish species with cheaper varieties or mislabelling of food unfit for human consumption is a global problem violating both consumers’ rights and safety. For distinguishing fish species in pure ... -
Dietary chlorpyrifos-methyl exposure impair transcription of immune-, detoxification- and redox signaling genes in leukocytes isolated from cod (Gadus morhua)
Holen, Elisabeth; Espe, Marit; Larsen, Anett Kristin; Olsvik, Pål Asgeir (Peer reviewed; Journal article, 2022)Inclusion of new environmental toxicants increase with the amount of plant ingredients substituting marine proteins and oils in feed for farmed Atlantic salmon (Salma salar). Agricultural pesticides like chlorpyrifos-methyl, ... -
Distinct polymer-dependent sorption of persistent pollutants associated with Atlantic salmon farming to microplastics
Abihssira Garcia, Isabel Sofia; Kögel, Tanja; Gomiero, Alessio; Kristensen, Torstein; Krogstad, Morten; Olsvik, Pål Asgeir (Peer reviewed; Journal article, 2022)Interactions of microplastics and persistent organic pollutants (POPs) associated with Atlantic salmon farming were studied to assess the potential role of microplastics in relation to the environmental impact of aquaculture. ... -
DNA damage and health effects in juvenile haddock (Melanogrammus aeglefinus) exposed to PAHs associated with oil-polluted sediment or produced water
Meier, Sonnich; Karlsen, Ørjan; Le Goff, Jérémie; Sørensen, Lisbet; Sørhus, Elin; Pampanin, Daniela Maria; Donald, Carey E.; Fjelldal, Per Gunnar; Dunaevskaya, Evgenia; Romano, Marta; Caliani, Ilaria; Casini, Silvia; Bogevik, Andre S.; Olsvik, Pål Asgeir; Myers, Mark; Grøsvik, Bjørn Einar (Peer reviewed; Journal article, 2020)The research objective was to study the presence of DNA damages in haddock exposed to petrogenic or pyrogenic polyaromatic hydrocarbons (PAHs) from different sources: 1) extracts of oil produced water (PW), dominated by ... -
Ecotoxicological assessment of Cu-rich acid mine drainage of Sulitjelma mine using zebrafish larvae as an animal model
Varshney, Shubham; Lundås, Mikkel; Siriyappagouder, Prabhugouda; Kristensen, Torstein; Olsvik, Pål Asgeir (Others, 2024)Acid mine drainage (AMD) is widely acknowledged as a substantial threat to the biodiversity of aquatic ecosystems. The present study aimed to study the toxicological effects of Cu-rich AMD from the Sulitjelma mine in ... -
Effects of Agricultural Pesticides in Aquafeeds on Wild Fish Feeding on Leftover Pellets Near Fish Farms
Olsvik, Pål Asgeir; Larsen, Anett Kristin; Berntssen, Marc; Goksøyr, Anders; Karlsen, Odd Andre; Yadetie, Fekadu; Sanden, Monica; Kristensen, Torstein (Others, 2019)Screening has revealed that modern-day feeds used in Atlantic salmon aquaculture might contain trace amounts of agricultural pesticides. To reach slaughter size, salmon are produced in open net pens in the sea. Uneaten ... -
Effects of agricultural pesticides in aquafeeds on wild fish feeding on leftover pellets near fish farms
Olsvik, Pål Asgeir; Larsen, Anett Kristin; Berntssen, Marc; Goksøyr, Anders; Karlsen, Odd Andre; Yadetie, Fekadu; Sanden, Monica; Kristensen, Torstein (Journal article; Peer reviewed, 2019)Screening has revealed that modern-day feeds used in Atlantic salmon aquaculture might contain trace amounts of agricultural pesticides. To reach slaughter size, salmon are produced in open net pens in the sea. Uneaten ... -
Effects of mine tailing exposure on early life stages of cod (Gadus morhua) and haddock (Melanogrammus aeglefinus)
Farkas, Julia; Nordtug, Trond; Svendheim, Linn Hjelmeland; D Amico, Elettra; Davies, Emlyn John; Ciesielski, Tomasz Maciej; Jensen, Bjørn Munro; Kristensen, Torstein; Olsvik, Pål Asgeir; Hansen, Bjørn Henrik (Peer reviewed; Journal article, 2021)Mining and processing of minerals produce large quantities of tailings as waste. Some countries, including Norway, allow disposal of mine tailings in the sea. In this study we investigated the impacts of tailings from a ... -
Effects of mining chemicals on fish: exposure to tailings containing Lilaflot D817M induces CYP1A transcription in Atlantic salmon smolt
Olsvik, Pål Asgeir; Urke, Henning Andre; Nilsen, Tom Ole; Ulvund, John Birger; Kristensen, Torstein (Journal article; Peer reviewed, 2015)Mine tailings, containing metals and production chemicals such as flotation chemicals and flocculants, may pose an environmental threat to aquatic organisms living in downstream ecosystems. The aim of this work was to study ... -
Environmentally realistic concentrations of chlorinated, brominated, and fluorinated persistent organic pollutants induce the unfolded protein response as a shared stress pathway in the liver of Atlantic cod (Gadus morhua)
Olsvik, Pål Asgeir; Meier, Sonnich; Zhang, Xiaokang; Goksøyr, Anders; Karlsen, Odd André; Yadetie, Fekadu (Peer reviewed; Journal article, 2023)In the North Sea and North Atlantic coastal areas, fish experience relatively high background levels of persistent organic pollutants. This study aimed to compare the mode of action of environmentally relevant concentrations ... -
In vitro toxicity of glyphosate in Atlantic salmon evaluated with a 3D hepatocyte-kidney co-culture model
Søfteland, Liv Ingeborg Rosvoll; Olsvik, Pål Asgeir (Peer reviewed; Journal article, 2022)A novel 3D Atlantic salmon co-culture model was developed using primary hepatocytes and kidney epithelial cells isolated from the same fish. Mono and co-cultures of primary hepatocytes and kidney epithelial cells were ... -
Lufenuron treatment temporarily represses gene expression and affects the SUMO pathway in liver of Atlantic salmon
Olsvik, Pål Asgeir; Brokke, Kristine Ertnæs; Samuelsen, Ole; Hannisdal, Rita (Peer reviewed; Journal article, 2023)Lufenuron is a benzoylurea insecticide currently in use to combat sea lice infestation in salmon aquaculture in Chile. With pending approval in Norway, the aim of this work was to study the uptake and toxicity of lufenuron ... -
Mixture toxicity of chlorpyrifos-methyl, pirimiphos-methyl, and nonylphenol in Atlantic salmon (Salmo salar) hepatocytes
Olsvik, Pål Asgeir; Søfteland, Liv Ingeborg Rosvoll (Peer reviewed; Journal article, 2020)Pesticide formulations typically contain adjuvants added to enhance the performance of the active ingredient. Adjuvants may modify the bioavailability and toxicity of pesticides. In this study, the aim was to examine to ... -
Modifying effects of vitamin E on chlorpyrifos toxicity in Atlantic salmon
Olsvik, Pål Asgeir; Berntssen, Marc; Søfteland, Liv Ingeborg Rosvoll (Peer reviewed; Journal article, 2015) -
Modifying effects of vitamin E on chlorpyrifos toxicity in Atlantic salmon
Olsvik, Pål Asgeir; Berntssen, Marc; Søfteland, Liv Ingeborg Rosvoll (Peer reviewed; Journal article, 2015) -
Offshore crude oil disrupts retinoid signaling and eye development in larval Atlantic haddock
Lie, Kai Kristoffer; Meier, Sonnich; Sørhus, Elin; Edvardsen, Rolf; Karlsen, Ørjan; Olsvik, Pål Asgeir (Journal article; Peer reviewed, 2019)The aim of this study was to examine the impact of dispersed crude oil on retinoid metabolism and signaling in developing haddock larvae (Melanogrammus aeglefinus). Retinoids and its active metabolites are involved in the ...