• Adipose MDM2 regulates systemic insulin sensitivity 

      Hallenborg, Philip; Jensen, Benjamin Anderschou Holbech; Fjære, Even; Petersen, Rasmus Koefoed; Belmaâti, Mohammed-Samir; Rasmussen, Sarah Søndergård; Gunnarsson, Jon Petur; Lauritzen, Pernille; Cheng, Kenneth King Yip; Hermansson, Martin; Sonne, Si Brask; Ejsing, Christer S.; Xu, Aimin; Kratchmarova, Irina; Krüger, Marcus; Madsen, Lise; Kristiansen, Karsten; Blagoev, Blagoy (Peer reviewed; Journal article, 2021)
      The intimate association between obesity and type II diabetes urges for a deeper understanding of adipocyte function. We and others have previously delineated a role for the tumor suppressor p53 in adipocyte biology. Here, ...
    • A catalog of microbial genes from the bovine rumen unveils a specialized and diverse biomass-degrading environment 

      Li, Junhua; Zhong, Huanzi; Ramayo-Caldas, Yuliaxis; Terrapon, Nicolas; Lombard, Vincent; Potocki-Veronese, Gabrielle; Estellé, Jordi; Popova, Milka; Yang, Ziyi; Zhang, Hui; Li, Fang; Tang, Shanmei; Yang, Fangming; Chen, Weineng; Chen, Bing; Li, Jiyang; Guo, Jing; Martin, Cécile; Maguin, Emmanuelle; Xu, Xun; Yang, Huanming; Wang, Jian; Madsen, Lise; Kristiansen, Karsten; Henrissat, Bernard; Ehrlich, Stanislav D; Morgavi, Diego P (Peer reviewed; Journal article, 2020)
      Background The rumen microbiota provides essential services to its host and, through its role in ruminant production, contributes to human nutrition and food security. A thorough knowledge of the genetic potential of rumen ...
    • Co-diversification of an intestinal Mycoplasma and its salmonid host 

      Rasmussen, Jacob A.; Kiilerich, Pia; Madhun, Abdullah Sami; Waagbø, Rune; Lock, Erik Jan Robert; Madsen, Lise; Gilbert, Marcus Thomas Pius; Kristiansen, Karsten; Limborg, Morten T. (Peer reviewed; Journal article, 2023)
      Understanding the evolutionary relationships between a host and its intestinal resident bacteria can transform how we understand adaptive phenotypic traits. The interplay between hosts and their resident bacteria inevitably ...
    • CRISPR/cascade 9-mediated genome editing-challenges and opportunities 

      Roy, Bhaskar; Zhao, Jing; Yang, Chao; Luo, Wen; Xiong, Teng; Li, Yong; Fang, Xiaodong; Gao, Guanjun; Singh, Chabungbam O; Madsen, Lise; Zhou, Yong; Kristiansen, Karsten (Journal article; Peer reviewed, 2018)
      Clustered Regularly Interspaced Palindromic Repeats (CRISPR) and Cascade 9 (also known as Cas9, CRISPR associated protein 9) confer protection against invading viruses or plasmids. The CRISPR/Cascade 9 system constitutes ...
    • Dietary Proteins, Brown Fat, and Adiposity 

      Madsen, Lise; Myrmel, Lene Secher; Fjære, Even; Øyen, Jannike; Kristiansen, Karsten (Journal article; Peer reviewed, 2018)
      High protein diets have become popular for body weight maintenance and weight loss despite controversies regarding efficacy and safety. Although both weight gain and weight loss are determined by energy consumption and ...
    • Distinct gut metagenomics and metaproteomics signatures in prediabetics and treatment-naive type 2 diabetics 

      Zhong, Huanzi; Ren, Huahui; Lu, Yan; Fang, Chao; Hou, Guixue; Yang, Ziyi; Chen, Bing; Yang, Fangming; Zhao, Yue; Shi, Zhun; Zhou, Baojin; Wu, Jiegen; Zou, Hua; Zi, Jin; Chen, Jiayu; Bao, Xiao; Hu, Yihe; Gao, Yan; Zhang, Jun; Xu, Xun; Hou, Yong; Yang, Huanming; Wang, Jian; Liu, Siqi; Jia, Huijue; Madsen, Lise; Brix, Susanne; Kristiansen, Karsten; Liu, Fang; Li, Junhua (Peer reviewed; Journal article, 2019)
      Background The gut microbiota plays important roles in modulating host metabolism. Previous studies have demonstrated differences in the gut microbiome of T2D and prediabetic individuals compared to healthy individuals, ...
    • Effects of exercise and dietary protein sources on adiposity and insulin sensitivity in obese mice 

      Fjære, Even; Myrmel, Lene Secher; Lützhøft, Ditte Olsen; Andersen, Hanne; Holm, Jacob Bak; Kiilerich, Pia; Hannisdal, Rita; Liaset, Bjørn; Kristiansen, Karsten; Madsen, Lise (Journal article; Peer reviewed, 2019)
      Low-fat diets and exercise are generally assumed to ameliorate obesity-related metabolic dysfunctions, but the importance of exercise vs. dietary changes is debated. Male C57BL/6J mice were fed a high-fat/high-sucrose ...
    • Effects of frozen storage on phospholipid content in atlantic cod fillets and the influence on diet-induced obesity in mice 

      Fauske, Kristin Røen; Bernhard, Annette; Fjære, Even; Myrmel, Lene Secher; Frøyland, Livar; Kristiansen, Karsten; Liaset, Bjørn; Madsen, Lise (Peer reviewed; Journal article, 2018)
    • An Expanded Gene Catalog of Mouse Gut Metagenomes 

      Zhu, Jiahui; Ren, Huahui; Zhong, Huanzi; Li, Xiaoping; Zou, Yuanqiang; Han, Mo; Li, Minli; Madsen, Lise; Kristiansen, Karsten; Xiao, Liang (Peer reviewed; Journal article, 2021)
      High-quality and comprehensive reference gene catalogs are essential for metagenomic research. The rather low diversity of samples used to construct existing catalogs of the mouse gut metagenome limits the numbers of ...
    • Lysates of Methylococcus capsulatus Bath induce a lean-like microbiota, intestinal FoxP3+RORγt+IL-17+ Tregs and improve metabolism 

      Jensen, Benjamin Anderschou Holbech; Holm, Jacob B.; Larsen, Ida S.; von Burg, Nicole; Derer, Stefanie; Sonne, Si B.; Pærrgaard, Simone I.; Damgaard, Mads V.; Indrelid, Stine Hufthammer; Rivollier, Aymeric; Agrinier, Anne-Laure; Sulek, Karolina; Arnoldussen, Yke Jildouw; Fjære, Even; Marette, André; Angell, Inga Leena; Rudi, Knut; Treebak, Jonas Thue; Madsen, Lise; Åkesson, Caroline Piercey; Agace, William; Sina, Christian; Kleiveland, Charlotte Ramstad; Kristiansen, Karsten; Lea, Tor Erling (Peer reviewed; Journal article, 2021)
      Interactions between host and gut microbial communities are modulated by diets and play pivotal roles in immunological homeostasis and health. We show that exchanging the protein source in a high fat, high sugar, westernized ...
    • Metabolic effects of diet containing blue mussel (Mytilus edulis) and blue mussel-fed salmon in a mouse model of obesity 

      Mahjour Azad, Atabak; Bernhard, Annette; Shen, Anne; Myrmel, Lene Secher; Lundebye, Anne-Katrine; Lecaudey, Laurene Alicia; Fjære, Even; Ho, Quang Tri; Sveier, Harald; Kristiansen, Karsten; Limborg, Morten Tønsberg; Madsen, Lise (Peer reviewed; Journal article, 2023)
      Alternative feed ingredients for farmed salmon are warranted due to increasing pressure on wild fish stocks. As locally farmed blue mussels may represent an environmentally sustainable substitute with a lower carbon ...
    • Metagenome-wide association of gut microbiome features for schizophrenia 

      Zhu, Feng; Ju, Yanmei; Wang, Wei; Wang, Qi; Guo, Ruijin; Ma, Qingyan; Sun, Qiang; Fan, Yajuan; Xie, Yuying; Yang, Zai; Jie, Zhuye; Zhao, Binbin; Xiao, Liang; Yang, Lin; Zhang, Tao; Feng, Junqin; Guo, Liyang; He, Xiaoyan; Chen, Yunchun; Chen, Ce; Gao, Chengge; Xu, Xun; Yang, Huanming; Wang, Jian; Dang, Yonghui; Madsen, Lise; Brix, Susanne; Kristiansen, Karsten; Jia, Huijue; Ma, Xiancang (Peer reviewed; Journal article, 2020)
      Evidence is mounting that the gut-brain axis plays an important role in mental diseases fueling mechanistic investigations to provide a basis for future targeted interventions. However, shotgun metagenomic data from ...
    • Network of Interactions Between Gut Microbiome, Host Biomarkers, and Urine Metabolome in Carotid Atherosclerosis 

      Li, Rui-Jun; Jie, Zhu-Ye; Feng, Qiang; Fang, Rui-Ling; Li, Fei; Gao, Yuan; Xia, Hui-Hua; Zhong, Huan-Zi; Tong, Bin; Madsen, Lise; Zhang, Jia-Hao; Liu, Chun-Lei; Xu, Zhen-Guo; Wang, Jian; Yang, Huan-Ming; Xu, Xun; Hou, Yong; Brix, Susanne; Kristiansen, Karsten; Yu, Xin-Lei; Jia, Hui-Jue; He, Kun-Lun (Peer reviewed; Journal article, 2021)
      Comprehensive analyses of multi-omics data may provide insights into interactions between different biological layers concerning distinct clinical features. We integrated data on the gut microbiota, blood parameters and ...
    • Overexpression of cyclooxygenase-2 in adipocytes reduces fat accumulation in inguinal white adipose tissue and hepatic steatosis in high-fat fed mice 

      Danneskiold-Samsø, Niels Banhos; Sonne, Si Brask; Larsen, Jeppe Madura; Ann Normann, Hansen; Fjære, Even; Isidor, Marie Sophie; Petersen, Sidsel; Henningsen, Jeanette; Severi, Ilenia; Sartini, Loris; Schober, Yvonne; Wolf, Jacqueline; Nockher, W. Andreas; Wolfrum, Christian; Cinti, Saverio; Sina, Christian; Hansen, Jacob B.; Madsen, Lise; Brix, Susanne; Kristiansen, Karsten (Journal article; Peer reviewed, 2019)
      Cyclooxygenases are known as important regulators of metabolism and immune processes via conversion of C20 fatty acids into various regulatory lipid mediators, and cyclooxygenase activity has been implicated in browning ...
    • Salmon in combination with high glycemic index carbohydrates increases diet-induced thermogenesis compared with salmon with low glycemic index carbohydrates?an acute randomized cross-over meal test study 

      Nielsen, Lone V.; Nyby, Signe; Klingenberg, Lars; Ritz, Christian; Sundekilde, Ulrik Kræmer; Bertram, Hanne Christine; Westerterp-Plantenga, Margriet S.; Liaset, Bjørn; Kristiansen, Karsten; Madsen, Lise; Raben, Anne (Journal article; Peer reviewed, 2019)
      The study investigated the acute effects of meals containing either salmon or veal in combination with carbohydrates with high or low glycemic index (GI) on diet-induced thermogenesis (DIT) (primary endpoint), appetite ...
    • Seafood intake and the development of obesity, insulin resistance and type 2 diabetes 

      Liaset, Bjørn; Øyen, Jannike; Jacques, Helene; Kristiansen, Karsten; Madsen, Lise (Journal article; Peer reviewed, 2019)
      We provide an overview of studies on seafood intake in relation to obesity, insulin resistance and type 2 diabetes. Overweight and obesity development is for most individuals the result of years of positive energy balance. ...
    • The anti-obesogenic effect of lean fish species is influenced by the fatty acid composition in fish fillets 

      Fjære, Even; Myrmel, Lene Secher; Dybing, Karianne; Kuda, Ondrej; Jensen, Benjamin Anderschou Holbech; Rossmeisl, Martin; Frøyland, Livar; Kristiansen, Karsten; Madsen, Lise (Peer reviewed; Journal article, 2020)
    • The impact of different animal-derived protein sources on adiposity and glucose homeostasis during ad libitum feeding and energy restriction in already obese mice 

      Myrmel, Lene Secher; Fauske, Kristin Røen; Fjære, Even; Bernhard, Annette; Liisberg, Ulrike; Hasselberg, Astrid Elise; Øyen, Jannike; Kristiansen, Karsten; Madsen, Lise (Journal article; Peer reviewed, 2019)
      Low-fat diets and energy restriction are recommended to prevent obesity and to induce weight loss, but high-protein diets are popular alternatives. However, the importance of the protein source in obesity prevention and ...
    • The metagenome of the female upper reproductive tract 

      Li, Fei; Chen, Chen; Wei, Weixia; Wang, Zirong; Dai, Juanjuan; Hao, Lilan; Song, Liju; Zhang, Xiaowei; Zeng, Liping; Du, Hui; Tang, Huiru; Liu, Na; Yang, Huanming; Wang, Jian; Madsen, Lise; Brix, Susanne; Kristiansen, Karsten; Xu, Xun; Li, Junhua; Wu, Ruifang; Jia, Huijue (Peer reviewed; Journal article, 2018)