• Analysis of immunoglobulin and T cell receptor gene expression in ballan wrasse (Labrus bergylta) revealed an extraordinarily high IgM expression in the gut 

      Bilal, Sumaira; Lie, Kai Kristoffer; Dalum, Alf Seljenes; Karlsen, Odd Andre; Hordvik, Ivar (Journal article; Peer reviewed, 2019)
      The serum IgM concentration of ballan wrasse is relatively high, estimated to approximately 13 mg/ml in adult wild fish of 800 g. The present study revealed an unusual high abundance of IgM mRNA in the gut of ballan wrasse. ...
    • Benzo(a)pyrene reduces osteoclast and osteoblast activity in ex-vivo scales of zebrafish (Danio rerio [Hamilton-Buchanan, 1822]) and goldfish (Carassius auratus [Linnaeus, 1758]) 

      Torvanger, Ivar; Metz, J. R.; Olsvik, Pål Asgeir; Søfteland, Liv Ingeborg Rosvoll; Lie, Kai Kristoffer (Journal article; Peer reviewed, 2018)
      Environmental contaminants have previously been demonstrated to cause bone deformities mediated through the aryl hydrocarbon receptor (AhR) in fish and mammals. Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous in the ...
    • Cardiac dysfunction affects eye development and vision by reducing supply of lipids in fish 

      Sørhus, Elin; Meier, Sonnich; Donald, Carey; Furmanek, Tomasz; Edvardsen, Rolf Brudvik; Lie, Kai Kristoffer (Peer reviewed; Journal article, 2021)
      Developing organisms are especially vulnerable to environmental stressors. Crude oil exposure in early life stages of fish result in multiple functional and developmental defects, including cardiac dysfunction and abnormal ...
    • Dietary Lipid Modulation of Intestinal Serotonin in Ballan Wrasse (Labrus bergylta)—In Vitro Analyses 

      Etayo, Angela; Le, Hoang Thi My Dung; Araujo, Pedro; Lie, Kai Kristoffer; Sæle, Øystein (Peer reviewed; Journal article, 2021)
      Serotonin (5-HT) is pivotal in the complex regulation of gut motility and consequent digestion of nutrients via multiple receptors. We investigated the serotonergic system in an agastric fish species, the ballan wrasse ...
    • Effects of cholecystokinin (CCK) on gut motility in the stomachless fish ballan wrasse (Labrus bergylta) 

      Le, Hoang Thi My Dung; Lie, Kai Kristoffer; Giroud-Argoud, Justine; Rønnestad, Ivar; Sæle, Øystein (Journal article; Peer reviewed, 2019)
      Cholecystokinin (CCK) is well-known as a key hormone that inhibits stomach emptying and stimulates midgut motility in gastric species. However, the function of CCK related to gut motility in agastric fish, especially in ...
    • Evaluation of potential reference genes in real-time RT-PCR studies of Atlantic salmon 

      Olsvik, Pål A.; Lie, Kai Kristoffer; Olderbakk Jordal, Anne-Lise; Nilsen, Tom Ole; Hordvik, Ivar (Journal article; Peer reviewed, 2005)
      Background Salmonid fishes are among the most widely studied model fish species but reports on systematic evaluation of reference genes in qRT-PCR studies is lacking. Results The stability of six potential reference ...
    • Intestinal function of the stomachless fish, ballan wrasse (Labrus bergylta) 

      Le, Hoang Thi My Dung; Shao, Xinting; Krogdahl, Åshild; Kortner, Trond Moxness; Lein, Ingrid; Kousoulaki, Katerina; Lie, Kai Kristoffer; Sæle, Øystein (Journal article; Peer reviewed, 2019)
      Little is known about the digestion of nutrients in stomachless (agastric) fishes with short intestines, such as wrasse. This study describes the digestion, absorption and evacuation rates in ballan wrasse (Labrus bergylta) ...
    • Kunnskapsstatus for havsil i norsk sone av Nordsjøen 

      Johnsen, Espen; Sørhus, Elin; de Jong, Karen; Lie, Kai Kristoffer; Grøsvik, Bjørn Einar (Rapport fra havforskningen;2021 - 33, Research report, 2021)
      Tobis eller havsil er en nøkkelart i økosystemet i Nordsjøen, og viktige gyte- og leveområder for havsil er identifisert som særlig verdifulle og sårbare områder (SVO) i Nordsjøen. Rapporten oppsummerer eksisterende kunnskap ...
    • Loss of stomach, loss of appetite? Sequencing of the ballan wrasse (Labrus bergylta) genome and intestinal transcriptomic profiling illuminate the evolution of loss of stomach function in fish 

      Lie, Kai Kristoffer; Tørresen, Ole K.; Solbakken, Monica Hongrø; Rønnestad, Ivar; Tooming-Klunderud, Ave; Nederbragt, Alexander Johan; Jentoft, Sissel; Sæle, Øystein (Journal article; Peer reviewed, 2018)
      The ballan wrasse (Labrus bergylta) belongs to a large teleost family containing more than 600 species showing several unique evolutionary traits such as lack of stomach and hermaphroditism. Agastric fish are found throughout ...
    • Offshore crude oil disrupts retinoid signaling and eye development in larval Atlantic haddock 

      Lie, Kai Kristoffer; Meier, Sonnich; Sørhus, Elin; Edvardsen, Rolf; Karlsen, Ørjan; Olsvik, Pål Asgeir (Journal article; Peer reviewed, 2019)
      The aim of this study was to examine the impact of dispersed crude oil on retinoid metabolism and signaling in developing haddock larvae (Melanogrammus aeglefinus). Retinoids and its active metabolites are involved in the ...
    • Ontogeny-Specific Skeletal Deformities in Atlantic Haddock Caused by Larval Oil Exposure 

      Olsvik, Pål Asgeir; Sørhus, Elin; Meier, Sonnich; Torvanger, Ingrid; Thorbjørnsen, Maja; Thorsen, Anders; Sørensen, Lisbet; Fjelldal, Per Gunnar; Karlsen, Ørjan; Guimaraes, Igo G.; Lie, Kai Kristoffer (Peer reviewed; Journal article, 2021)
      Bone deformities are one of the main effects of crude oil exposure in marine fish larvae. Craniofacial and jaw deformities, if severe enough, may restrict feeding and ultimately kill the developing larvae. This study aimed ...
    • Ossification of Atlantic cod (Gadus morhua) – Developmental stages revisited 

      Sæle, Øystein; Haugen, Trine; Karlsen, Ørjan; van der Meeren, Terje; Bæverfjord, Grete; Hamre, Kristin; Rønnestad, Ivar; Moren, Mari; Lie, Kai Kristoffer (Peer reviewed; Journal article, 2017)
      In studies of marine larvae, it is common to use days post-hatch as a developmental reference point. We show that age is a poor measure of morphological and physiological development in Atlantic cod. Therefore, we propose ...
    • Ossification of Atlantic cod (Gadus morhua) – Developmental stages revisited 

      Sæle, Øystein; Haugen, Trine; Karlsen, Ørjan; van der Meeren, Terje; Bæverfjord, Grete; Hamre, Kristin; Rønnestad, Ivar; Moren, Mari; Lie, Kai Kristoffer (Peer reviewed; Journal article, 2017)
      In studies of marine larvae, it is common to use days post-hatch as a developmental reference point. We show that age is a poor measure of morphological and physiological development in Atlantic cod. Therefore, we propose ...
    • Parental high dietary arachidonic acid levels modulated the hepatic transcriptome of adult zebrafish (Danio rerio) progeny 

      Adam, Anne-Catrin; Skjærven, Kaja Helvik; Whatmore, Paul; Moren, Mari; Lie, Kai Kristoffer (Journal article; Peer reviewed, 2018)
      Disproportionate high intake of n-6 polyunsaturated fatty acids (PUFAs) in the diet is considered as a major human health concern. The present study examines changes in the hepatic gene expression pattern of adult male ...
    • Pharmacokinetics and transcriptional effects of the anti-salmon lice drug emamectin benzoate in Atlantic salmon (Salmo salar L.) 

      Olsvik, Pål Asgeir; Lie, Kai Kristoffer; Mykkeltvedt, Eva; Samuelsen, Ole Bent; Petersen, Kjell; Stavrum, Anne-Kristin; Lunestad, Bjørn Tore (Journal article, 2008)
      Background Emamectin benzoate (EB) is a dominating pharmaceutical drug used for the treatment and control of infections by sea lice (Lepeophtheirus salmonis) on Atlantic salmon (Salmo salar L). Fish with an initial mean ...
    • Profiling DNA methylation patterns of zebrafish liver associated with parental high dietary arachidonic acid. 

      Adam, Anne-Catrin; Lie, Kai Kristoffer; Whatmore, Paul; Jakt, Lars Martin; Moren, Mari; Skjærven, Kaja Helvik (Journal article; Peer reviewed, 2019)
      Diet has been shown to influence epigenetic key players, such as DNA methylation, which can regulate the gene expression potential in both parents and offspring. Diets enriched in omega-6 and deficient in omega-3 PUFAs ...
    • Program for fremmedstoffer i fôrmidler av fisk - Rapport for innsamlede prøver 2019 

      Lundebye, Anne-Katrine; Bakkejord, Jannicke Alling; Nøstbakken, Ole Jakob; Lie, Kai Kristoffer; Sele, Veronika; Ørnsrud, Robin (Rapport fra havforskningen;2020 - 40, Research report, 2020)
      Mattilsynet er oppdragsgiver for dette overvåkningsprogrammet, som har som formål å undersøke innholdet av fremmedstoffer i fôrmidler av fisk, og som gjennomføres ved Havforskningsinstituttet. Overvåkingsprogrammet supplerer ...
    • Program for overvåking av fiskefôr 

      Sele, Veronika; Sanden, Monica; Berntssen, Marc; Lunestad, Bjørn Tore; Espe, Marit; Lie, Kai Kristoffer; Amlund, Heidi; Lundebye, Anne-Katrine; Hemre, Gro Ingunn; Waagbø, Rune; Ørnsrud, Robin (Rapport fra havforskningen;25-2018, Research report, 2018)
      Mattilsynet er oppdragsgiver for denne overvåkningen som er en del av Norges oppfølging av nasjonalt og internasjonalt regelverk på dyrefôr. Denne rapporten oppsummerer resultater fra det offentlige overvåknings- og ...
    • Program for overvåking av fiskefôr - Årsapport for prøver innsamlet i 2020 

      Sele, Veronika; Berntssen, Marc HG; Prabhu, P. Antony Jesu; Lundebye, Anne-Katrine; Lie, Kai Kristoffer; Espe, Marit; Storesund, Julia Endresen; Ørnsrud, Robin (Rapport fra havforskningen;2021 - 28, Research report, 2021)
      Overvåknings- og kartleggingsprogrammet for fiskefôr utføres på vegne av Mattilsynet. I 2020 ankom det 85 fiskefôr, 9 fiskemel, 9 vegetabilske mel, 10 fiskeoljer, 8 vegetabilske oljer, 4 insektmel og 16 premikser som ble ...
    • Program for overvåking av fiskefôr - Årsrapport for prøver innsamlet i 2018 

      Sele, Veronika; Sanden, Monica; Berntssen, Marc; Storesund, Julia Endresen; Lie, Kai Kristoffer; Espe, Marit; Lundebye, Anne-Katrine; Hemre, Gro Ingunn; Waagbø, Rune; Ørnsrud, Robin (Rapport fra havforskningen;2019 - 30, Research report, 2019)
      Mattilsynet er oppdragsgiver for denne overvåkningen som er en del av Norges oppfølging av nasjonalt og internasjonalt regelverk på dyrefôr. Denne rapporten oppsummerer resultater fra det offentlige overvåknings- og ...