Browsing Brage IMR by Author "Lie, Kai Kristoffer"
Now showing items 1-20 of 42
-
Analysis of immunoglobulin and T cell receptor gene expression in ballan wrasse (Labrus bergylta) revealed an extraordinarily high IgM expression in the gut
Bilal, Sumaira; Lie, Kai Kristoffer; Dalum, Alf Seljenes; Karlsen, Odd Andre; Hordvik, Ivar (Journal article; Peer reviewed, 2019)The serum IgM concentration of ballan wrasse is relatively high, estimated to approximately 13 mg/ml in adult wild fish of 800 g. The present study revealed an unusual high abundance of IgM mRNA in the gut of ballan wrasse. ... -
Beauvericin (BEA) and enniatin B (ENNB)-induced impairment of mitochondria and lysosomes - potential sources of intracellular reactive iron triggering ferroptosis in Atlantic salmon primary hepatocytes
Søderstrøm, Karin Sofie; Lie, Kai Kristoffer; Lundebye, Anne-Katrine; Søfteland, Liv Ingeborg Rosvoll (Peer reviewed; Journal article, 2022)Beauvericin (BEA) and enniatin B (ENNB) are emerging mycotoxins frequently detected in plant-based fish feed. With ionophoric properties, they have shown cytotoxic potential in mammalian models. Sensitivity in fish is still ... -
Benzo(a)pyrene reduces osteoclast and osteoblast activity in ex-vivo scales of zebrafish (Danio rerio [Hamilton-Buchanan, 1822]) and goldfish (Carassius auratus [Linnaeus, 1758])
Torvanger, Ivar; Metz, J. R.; Olsvik, Pål Asgeir; Søfteland, Liv Ingeborg Rosvoll; Lie, Kai Kristoffer (Journal article; Peer reviewed, 2018)Environmental contaminants have previously been demonstrated to cause bone deformities mediated through the aryl hydrocarbon receptor (AhR) in fish and mammals. Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous in the ... -
Cardiac dysfunction affects eye development and vision by reducing supply of lipids in fish
Sørhus, Elin; Meier, Sonnich; Donald, Carey; Furmanek, Tomasz; Edvardsen, Rolf Brudvik; Lie, Kai Kristoffer (Peer reviewed; Journal article, 2021)Developing organisms are especially vulnerable to environmental stressors. Crude oil exposure in early life stages of fish result in multiple functional and developmental defects, including cardiac dysfunction and abnormal ... -
Co-exposure to UV radiation and crude oil increases acute embryotoxicity and sublethal malformations in the early life stages of Atlantic haddock (Melanogrammus aeglefinus)
Sørhus, Elin; Donald, Carey; Nakken, Charlotte L.; Perrichon, Prescilla; Durif, Caroline; Shema, Steven; Browman, Howard; Skiftesvik, Anne Berit; Lie, Kai Kristoffer; Rasinger, Josef; Müller, Mette Helen Bjørge; Meier, Sonnich (Peer reviewed; Journal article, 2023)Crude oil causes severe abnormalities in developing fish. Photomodification of constituents in crude oil increases its toxicity several fold. We report on the effect of crude oil, in combination with ultraviolet (UV) ... -
Comparing novel shotgun DNA sequencing and state-of-the-art proteomics approaches for authentication of fish species in mixed samples
Varunjikar, Madhushri S.; Moreno-Ibarguen, Carlos; Andrade-Martinez, Juan S.; Tung, Hui-Shan; Belghit, Ikram; Palmblad, Magnus; Olsvik, Pål Asgeir; Reyes, Alejandro; Rasinger, Josef; Lie, Kai Kristoffer (Others, 2021)Replacement of high-value fish species with cheaper varieties or mislabelling of food unfit for human consumption is a global problem violating both consumers’ rights and safety. For distinguishing fish species in pure ... -
Dietary beauvericin and enniatin B exposure cause different adverse health effects in farmed Atlantic salmon
Berntssen, Marc HG; Fjelldal, Per Gunnar; Gavaia, P.J.; Laizé, V.; Hamre, Kristin; Donald, Carey; Jakobsen, J.V.; Omdal, A.; Søderstrøm, Karin Sofie; Lie, Kai Kristoffer (Peer reviewed; Journal article, 2023)The extensive use of plant ingredients in novel aquafeeds have introduced mycotoxins to the farming of seafood. The emerging enniatin B (ENNB) and beauvericin (BEA) mycotoxins have been found in the novel aquafeeds and ... -
Dietary Lipid Modulation of Intestinal Serotonin in Ballan Wrasse (Labrus bergylta)—In Vitro Analyses
Etayo, Angela; Le, Hoang Thi My Dung; Araujo, Pedro; Lie, Kai Kristoffer; Sæle, Øystein (Peer reviewed; Journal article, 2021)Serotonin (5-HT) is pivotal in the complex regulation of gut motility and consequent digestion of nutrients via multiple receptors. We investigated the serotonergic system in an agastric fish species, the ballan wrasse ... -
Dietary selenomethionine reduce mercury tissue levels and modulate methylmercury induced proteomic and transcriptomic alterations in hippocampi of adolescent BALB/c mice
Mellingen, Ragnhild Marie; Myrmel, Lene Secher; Rasinger, Josef; Lie, Kai Kristoffer; Bernhard, Annette; Madsen, Lise; Nøstbakken, Ole Jakob (Peer reviewed; Journal article, 2022)Methylmercury (MeHg) is a well-known environmental contaminant, particularly harmful to the developing brain. The main human dietary exposure to MeHg occurs through seafood consumption. However, seafood also contains several ... -
Effects of cholecystokinin (CCK) on gut motility in the stomachless fish ballan wrasse (Labrus bergylta)
Le, Hoang Thi My Dung; Lie, Kai Kristoffer; Giroud-Argoud, Justine; Rønnestad, Ivar; Sæle, Øystein (Journal article; Peer reviewed, 2019)Cholecystokinin (CCK) is well-known as a key hormone that inhibits stomach emptying and stimulates midgut motility in gastric species. However, the function of CCK related to gut motility in agastric fish, especially in ... -
Enniatin B and beauvericin affect intestinal cell function and hematological processes in Atlantic salmon (Salmo salar) after acute exposure
Söderström, Sofie Karin; Søfteland, Liv Ingeborg Rosvoll; Sele, Veronika; Lundebye, Anne-Katrine; Berntssen, Marc HG; Lie, Kai Kristoffer (Peer reviewed; Journal article, 2023)Unintentional use of mold-infested plant-based feed ingredients are sources of mycotoxins in fish feeds. The presence of the emerging mycotoxins ENNB and BEA in Norwegian commercial fish feeds and plant-based feed ingredients ... -
Evaluation of potential reference genes in real-time RT-PCR studies of Atlantic salmon
Olsvik, Pål A.; Lie, Kai Kristoffer; Olderbakk Jordal, Anne-Lise; Nilsen, Tom Ole; Hordvik, Ivar (Journal article; Peer reviewed, 2005)Background Salmonid fishes are among the most widely studied model fish species but reports on systematic evaluation of reference genes in qRT-PCR studies is lacking. Results The stability of six potential reference ... -
Future feed control – Tracing banned bovine material in insect meal
Belghit, Ikram; Varunjikar, Madhushri Shrikant; Lecrenier, Marie-Caroline; Steinhilber, A.; Niedzwiecka, A.; Wang, Y.V.; Dieu, Marc; Azzollini, D.; Lie, Kai Kristoffer; Lock, Erik Jan Robert; Berntssen, Marc HG; Renard, Patricia; Zagon, Jutta; Fumière, Olivier; van Loon, Loon; Larsen, Thomas; Poetz, O.; Braeuning, Albert; Palmblad, Magnus; Rasinger, Josef (Peer reviewed; Journal article, 2021)In the present study, we assessed if different legacy and novel molecular analyses approaches can detect and trace prohibited bovine material in insects reared to produce processed animal protein (PAP). Newly hatched black ... -
Intestinal function of the stomachless fish, ballan wrasse (Labrus bergylta)
Le, Hoang Thi My Dung; Shao, Xinting; Krogdahl, Åshild; Kortner, Trond Moxness; Lein, Ingrid; Kousoulaki, Katerina; Lie, Kai Kristoffer; Sæle, Øystein (Journal article; Peer reviewed, 2019)Little is known about the digestion of nutrients in stomachless (agastric) fishes with short intestines, such as wrasse. This study describes the digestion, absorption and evacuation rates in ballan wrasse (Labrus bergylta) ... -
Kunnskapsstatus for havsil i norsk sone av Nordsjøen
Johnsen, Espen; Sørhus, Elin; de Jong, Karen; Lie, Kai Kristoffer; Grøsvik, Bjørn Einar (Rapport fra havforskningen;2021 - 33, Research report, 2021)Tobis eller havsil er en nøkkelart i økosystemet i Nordsjøen, og viktige gyte- og leveområder for havsil er identifisert som særlig verdifulle og sårbare områder (SVO) i Nordsjøen. Rapporten oppsummerer eksisterende kunnskap ... -
Loss of stomach, loss of appetite? Sequencing of the ballan wrasse (Labrus bergylta) genome and intestinal transcriptomic profiling illuminate the evolution of loss of stomach function in fish
Lie, Kai Kristoffer; Tørresen, Ole K.; Solbakken, Monica Hongrø; Rønnestad, Ivar; Tooming-Klunderud, Ave; Nederbragt, Alexander Johan; Jentoft, Sissel; Sæle, Øystein (Journal article; Peer reviewed, 2018)The ballan wrasse (Labrus bergylta) belongs to a large teleost family containing more than 600 species showing several unique evolutionary traits such as lack of stomach and hermaphroditism. Agastric fish are found throughout ... -
Multi-tissue proteogenomic analysis for mechanistic toxicology studies in non-model species
Lin, M.S.; Varunjikar, Madhushri Shrikant; Lie, Kai Kristoffer; Søfteland, Liv Ingeborg Rosvoll; Dellafiora, L.; Ørnsrud, Robin; Sanden, Monica; Berntssen, Marc HG; Dorne, J.L.C.M.; Bafna, V.; Rasinger, Josef (Peer reviewed; Journal article, 2023)New approach methodologies (NAM), including omics and in vitro approaches, are contributing to the implementation of 3R (reduction, refinement and replacement) strategies in regulatory science and risk assessment. In this ... -
Offshore crude oil disrupts retinoid signaling and eye development in larval Atlantic haddock
Lie, Kai Kristoffer; Meier, Sonnich; Sørhus, Elin; Edvardsen, Rolf; Karlsen, Ørjan; Olsvik, Pål Asgeir (Journal article; Peer reviewed, 2019)The aim of this study was to examine the impact of dispersed crude oil on retinoid metabolism and signaling in developing haddock larvae (Melanogrammus aeglefinus). Retinoids and its active metabolites are involved in the ... -
Ontogeny-Specific Skeletal Deformities in Atlantic Haddock Caused by Larval Oil Exposure
Olsvik, Pål Asgeir; Sørhus, Elin; Meier, Sonnich; Torvanger, Ingrid; Thorbjørnsen, Maja; Thorsen, Anders; Sørensen, Lisbet; Fjelldal, Per Gunnar; Karlsen, Ørjan; Guimaraes, Igo G.; Lie, Kai Kristoffer (Peer reviewed; Journal article, 2021)Bone deformities are one of the main effects of crude oil exposure in marine fish larvae. Craniofacial and jaw deformities, if severe enough, may restrict feeding and ultimately kill the developing larvae. This study aimed ... -
Ossification of Atlantic cod (Gadus morhua) – Developmental stages revisited
Sæle, Øystein; Haugen, Trine; Karlsen, Ørjan; van der Meeren, Terje; Bæverfjord, Grete; Hamre, Kristin; Rønnestad, Ivar; Moren, Mari; Lie, Kai Kristoffer (Peer reviewed; Journal article, 2017)In studies of marine larvae, it is common to use days post-hatch as a developmental reference point. We show that age is a poor measure of morphological and physiological development in Atlantic cod. Therefore, we propose ...