Browsing Brage IMR by Author "Hordvik, Ivar"
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Analysis of immunoglobulin and T cell receptor gene expression in ballan wrasse (Labrus bergylta) revealed an extraordinarily high IgM expression in the gut
Bilal, Sumaira; Lie, Kai Kristoffer; Dalum, Alf Seljenes; Karlsen, Odd Andre; Hordvik, Ivar (Journal article; Peer reviewed, 2019)The serum IgM concentration of ballan wrasse is relatively high, estimated to approximately 13 mg/ml in adult wild fish of 800 g. The present study revealed an unusual high abundance of IgM mRNA in the gut of ballan wrasse. ... -
Comparative analysis of IgM sub-variants in salmonid fish and identification of a residue in mu 3 which is essential for MAb4C10 reactivity
Kamil, Atif; Raae, Arnt Johan; Fjelldal, Per Gunnar; Koppang, Erling Olaf; Fladmark, Kari Espolin; Hordvik, Ivar (Journal article; Peer reviewed, 2013)In rainbow trout (Onchorhynchus mykiss) it has been shown that high affinity IgM antibodies havea higher degree of disulfide polymerization and a longer half life time. In the present study, distinct IgMsub-variants related ... -
The Distribution of IgT mRNA+ Cells in the Gut of the Atlantic Salmon (Salmo salar L.)
Castro, Pedro Luis; Barac, Fran; Hansen, Tom Johnny; Fjelldal, Per Gunnar; Hordvik, Ivar; Bjørgen, Håvard; Koppang, Erling Olaf (Peer reviewed; Journal article, 2023)The newly discovered IgT+ B cell is thought to play a dominant role in mucosal immunity, but limited studies have examined its distribution in fish species, hindering our understanding of its function. This study investigated ... -
Evaluation of potential reference genes in real-time RT-PCR studies of Atlantic salmon
Olsvik, Pål A.; Lie, Kai Kristoffer; Olderbakk Jordal, Anne-Lise; Nilsen, Tom Ole; Hordvik, Ivar (Journal article; Peer reviewed, 2005)Background Salmonid fishes are among the most widely studied model fish species but reports on systematic evaluation of reference genes in qRT-PCR studies is lacking. Results The stability of six potential reference ... -
Organisation of the Atlantic salmon (Salmo salar) thymus and its content of Ig-expressing cells
Bjørgen, Håvard; Barac, Fran; Fjelldal, Per Gunnar; Hansen, Tom Johnny; Hordvik, Ivar; Koppang, Erling Olaf (Peer reviewed; Journal article, 2024)The thymus of fishes is located as a dual organ in a rostrodorsal projection within the gill chamber and is covered by the operculum. The histological organization of the teleost fish thymus displays considerable diversity, ... -
T cell receptor alpha chain genes in the teleost Ballan wrasse (Labrus bergylta) are subjected to somatic hypermutation
Bilal, Sumaira; Lie, Kai Kristoffer; Sæle, Øystein; Hordvik, Ivar (Journal article; Peer reviewed, 2018)Previously, somatic hypermutation (SHM) was considered to be exclusively associated with affinity maturation of antibodies, although it also occurred in T cells under certain conditions. More recently, it has been shown ... -
The thymus and T-cell ontogeny in ballan wrasse (Labrus bergylta) is nutritionally modelled
Etayo, Angela; Lie, Kai Kristoffer; Bjelland, Reidun Marie; Hordvik, Ivar; Øvergård, Aina-Cathrine; Sæle, Øystein (Peer reviewed; Journal article, 2023)Marine fish larvae often experience high mortality unrelated to predation during early life stages, and farmed ballan wrasse (Labrus bergylta) is no exception. Knowing when the adaptive immune system is developed and fully ...