Browsing Brage IMR by Author "Edvardsen, Rolf"
Now showing items 1-19 of 19
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An improved genome assembly uncovers prolific tandem repeats in Atlantic cod
Tørresen, Ole Kristian; Star, Bastiaan; Jentoft, Sissel; Reinar, William Brynildsen; Grove, Harald; Miller, Jason R.; Walenz, Brian; Knight, James; Ekholm, Jenny M.; Peluso, Paul; Edvardsen, Rolf; Tooming-Klunderud, Ave; Skage, Morten; Lien, Sigbjørn; Jakobsen, Kjetill Sigurd; Nederbragt, Alexander Johan (Peer reviewed; Journal article, 2017) -
Atlantic salmon populations reveal adaptive divergence of immune related genes - A duplicated genome under selection
Kjærner-Semb, Erik Nordtorp; Ayllon, Fernando; Furmanek, Tomasz; Wennevik, Vidar; Dahle, Geir; Niemelä, Eero; Ozerov, Mikhail; Vähä, Juha-Pekka; Glover, Kevin; Rubin, Carl J.; Wargelius, Anna; Edvardsen, Rolf (Journal article, 2016) -
CRISPR/Cas9-mediated ablation of elovl2 in Atlantic salmon (Salmo salar L.) inhibits elongation of polyunsaturated fatty acids and induces Srebp-1 and target genes
Winge, Per; Datsomor, Alex; Olsen, Rolf Erik; Jin, Yang; Vik, Jon Olav; Edvardsen, Rolf; Grammes, Fabian; Wargelius, Anna; Li, Keshuai (Journal article; Peer reviewed, 2019)Atlantic salmon can synthesize polyunsaturated fatty acids (PUFAs), such as eicosapentaenoic acid (20:5n-3), arachidonic acid (20:4n-6) and docosahexaenoic acid (22:6n-3) via activities of very long chain fatty acyl elongases ... -
Crude oil exposures reveal roles for intracellular calcium cycling in haddock craniofacial and cardiac development
Sørhus, Elin; Incardona, John P.; Karlsen, Ørjan; Linbo, Tiffany; Sørensen, Lisbet; Nordtug, Trond; van der Meeren, Terje; Thorsen, Anders; Thorbjørnsen, Maja; Jentoft, Sissel; Edvardsen, Rolf; Meier, Sonnich (Journal article; Peer reviewed, 2016-08-10)Recent studies have shown that crude oil exposure affects cardiac development in fish by disrupting excitation-contraction (EC) coupling. We previously found that eggs of Atlantic haddock (Melanogrammus aeglefinus) bind ... -
Diet affects the redox system in developing Atlantic cod(Gadus morhua) larvae
Penglase, Samuel; Edvardsen, Rolf; Furmanek, Tomasz; Rønnestad, Ivar; Karlsen, Ørjan; van der Meeren, Terje; Hamre, Kristin (Journal article; Peer reviewed, 2015-06-12)The growth and development of marine fish larvae fed copepods is superior to those fed rotifers, but the underlying molecular reasons for this are unclear. In the following study we compared the effects of such diets on ... -
Dnd knockout ablates germ cells and demonstrates germ cell independent sex differentiation in Atlantic salmon
Wargelius, Anna; Leininger, Sven Dirk; Skaftnesmo, Kai Ove; Kleppe, Lene; Andersson, Eva; Taranger, Geir Lasse; Schulz, Rüdiger W.; Edvardsen, Rolf (Journal article; Peer reviewed, 2016-02-18)Introgression of farmed salmon escapees into wild stocks is a major threat to the genetic integrity of wild populations. Using germ cell-free fish in aquaculture may mitigate this problem. Our study investigated whether ... -
The exorhodopsin and melanopsin systems in the pineal complex and brain at early developmental stages of Atlantic halibut (Hippoglossus hippoglossus)
Eilertsen, Mariann; Drivenes, Øyvind; Edvardsen, Rolf; Bradley, Clarissa A.; Ebbesson, Lars O.E.; Helvik, Jon Vidar (Peer reviewed; Journal article, 2014)The complexity of the nonvisual photoreception systems in teleosts has just started to be appreciated, with colocalization of multiple photoreceptor types with unresolved functions. Here we describe an intricate expression ... -
Genomic architecture of haddock (Melanogrammus aeglefinus) shows expansions of innate immune genes and short tandem repeats
Tørresen, Ole K.; Brieuc, Marine Servane; Solbakken, Monica Hongrø; Sørhus, Elin; Nederbragt, Alexander Johan; Jakobsen, Kjetill Sigurd; Meier, Sonnich; Edvardsen, Rolf; Jentoft, Sissel (Journal article; Peer reviewed, 2018)Increased availability of genome assemblies for non-model organisms has resulted in invaluable biological and genomic insight into numerous vertebrates, including teleosts. Sequencing of the Atlantic cod (Gadus morhua) ... -
Integrative testis transcriptome analysis reveals differentially expressed miRNAs and their mRNA targets during early puberty in Atlantic salmon
Skaftnesmo, Kai Ove; Edvardsen, Rolf; Furmanek, Tomasz; Crespo, D.; Andersson, Eva; Kleppe, Lene; Taranger, Geir Lasse; Bogerd, Jan; Schulz, Rüdiger W.; Wargelius, Anna (Peer reviewed; Journal article, 2017) -
Novel adverse outcome pathways revealed by chemical genetics in a developing marine fish
Sørhus, Elin; Incardona, John P.; Furmanek, Tomasz; Goetz, Giles W.; Scholz, Nathaniel; Meier, Sonnich; Edvardsen, Rolf; Jentoft, Sissel (Peer reviewed; Journal article, 2017)Crude oil spills are a worldwide ocean conservation threat. Fish are particularly vulnerable to the oiling of spawning habitats, and crude oil causes severe abnormalities in embryos and larvae. However, the underlying ... -
Offshore crude oil disrupts retinoid signaling and eye development in larval Atlantic haddock
Lie, Kai Kristoffer; Meier, Sonnich; Sørhus, Elin; Edvardsen, Rolf; Karlsen, Ørjan; Olsvik, Pål Asgeir (Journal article; Peer reviewed, 2019)The aim of this study was to examine the impact of dispersed crude oil on retinoid metabolism and signaling in developing haddock larvae (Melanogrammus aeglefinus). Retinoids and its active metabolites are involved in the ... -
Potential of genome editing to improve aquaculture breeding and production
Gratacap, Remi L.; Wargelius, Anna; Edvardsen, Rolf; Houston, Ross D. (Journal article; Peer reviewed, 2019)Aquaculture is an increasingly important component of global food security, and there is major potential for genetic improvement to contribute to sustainable production. The high fecundity and external fertilisation of ... -
Sex steroid production associated with puberty is absent in germ cellfree salmon
Kleppe, Lene; Andersson, Eva; Skaftnesmo, Kai Ove; Edvardsen, Rolf; Fjelldal, Per Gunnar; Norberg, Birgitta; Bogerd, Jan; Schulz, Rüdiger W.; Wargelius, Anna (Peer reviewed; Journal article, 2017) -
The genome sequence of Atlantic cod reveals a unique immune system
Star, Bastiaan; Nederbragt, Alexander Johan; Jentoft, Sissel; Grimholt, Unni; Malmstrøm, Martin; Gregers, Tone Fredsvik; Rounge, Trine Ballestad; Paulsen, Jonas; Solbakken, Monica Hongrø; Sharma, Animesh; Wetten, Ola Frang; Lanzén, Anders; Winer, Roger; Knight, James; Vogel, Jan-Hinnerk; Aken, Bronwen; Andersen, Øivind; Lagesen, Karin; Tooming-Klunderud, Ave; Edvardsen, Rolf; Kirubakaran, G. Tina; Espelund, Mari; Nepal, Chirag; Previti, A. Christopher; Karlsen, Bård Ove; Moum, Truls; Skage, Morten; Berg, Paul Ragnar; Gjøen, Tor; Kuhl, Heiner; Thorsen, Jim; Malde, Ketil; Reinhardt, Richard; Du, Lei; Johansen, Steinar Daae; Searle, Steve; Lien, Sigbjørn; Nilsen, Frank; Jonassen, Inge; Omholt, Stig W; Stenseth, Nils Christian; Jakobsen, Kjetill Sigurd (Journal article; Peer reviewed, 2011) -
The influence of vgll3 genotypes on sea age at maturity is altered in farmed mowi strain Atlantic salmon
Ayllon, Fernando; Solberg, Monica Favnebøe; Glover, Kevin; Mohammadi, Faezeh; Kjærner-Semb, Erik Nordtorp; Fjelldal, Per Gunnar; Andersson, Eva; Hansen, Tom Johnny; Edvardsen, Rolf; Wargelius, Anna (Journal article; Peer reviewed, 2019)Background: In Atlantic salmon in the wild, age at maturity is strongly influenced by the vgll3 locus. Under farming conditions, light, temperature and feeding regimes are known significantly advance or delay age at ... -
The initiation of puberty in Atlantic salmon brings about large changes in testicular gene expression that are modulated by the energy status
Crespo, Diego; Bogerd, Jan; Sambroni, Elisabeth; LeGac, Florence; Andersson, Eva; Edvardsen, Rolf; Bergman, Elisabeth Jonsson; Björnsson, Björn Thrandur; Taranger, Geir Lasse; Schulz, Rüdiger W. (Journal article; Peer reviewed, 2019)Background When puberty starts before males reach harvest size, animal welfare and sustainability issues occur in Atlantic salmon (Salmo salar) aquaculture. Hallmarks of male puberty are an increased proliferation activity ... -
The two-step development of a duplex retina involves distinct events of cone and rod neurogenesis and differentiation
Valen, Ragnhild; Eilertsen, Mariann; Edvardsen, Rolf; Furmanek, Tomasz; Rønnestad, Ivar; van der Meeren, Terje; Karlsen, Ørjan; Nilsen, Tom Ole; Helvik, Jon Vidar (Peer reviewed; Journal article, 2016) -
The vgll3 Locus Controls Age at Maturity in Wild and Domesticated Atlantic Salmon(Salmo salar L.) Males
Ayllon, Fernando; Kjærner-Semb, Erik Nordtorp; Furmanek, Tomasz; Wennevik, Vidar; Solberg, Monica Favnebøe; Dahle, Geir; Taranger, Geir Lasse; Glover, Kevin; Sällman Almèn, Markus; Rubin, Carl J.; Edvardsen, Rolf; Wargelius, Anna (Journal article; Peer reviewed, 2015-11-09)Wild and domesticated Atlantic salmon males display large variation for sea age at sexual maturation, which varies between 1–5 years. Previous studies have uncovered a genetic predisposition for variation of age at maturity ... -
Vgll3 and the Hippo pathway are regulated in Sertoli cells upon entry and during puberty in Atlantic salmon testis
Kjærner-Semb, Erik Nordtorp; Ayllon, Fernando; Kleppe, Lene; Sørhus, Elin; Skaftnesmo, Kai Ove; Furmanek, Tomasz; Segafredo, Frida Thyri; Thorsen, Anders; Fjelldal, Per Gunnar; Hansen, Tom Johnny; Taranger, Geir Lasse; Andersson, Eva; Schulz, Rüdiger W.; Wargelius, Anna; Edvardsen, Rolf (Journal article; Peer reviewed, 2018)Vgll3 is linked to age at maturity in Atlantic salmon (Salmo salar). However, the molecular mechanisms involving Vgll3 in controlling timing of puberty as well as relevant tissue and cell types are currently unknown. Vgll3 ...