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dc.contributor.authorChauvigné, Francois
dc.contributor.authorDucat, Carla
dc.contributor.authorFerré, Alba
dc.contributor.authorHansen, Tom Johnny
dc.contributor.authorCarrascal, Montserrat
dc.contributor.authorAbián, Joaquín
dc.contributor.authorFinn, Roderick Nigel
dc.contributor.authorCerdà, Joan
dc.date.accessioned2022-04-22T10:50:54Z
dc.date.available2022-04-22T10:50:54Z
dc.date.created2021-09-06T16:48:38Z
dc.date.issued2021
dc.identifier.citationProceedings of the National Academy of Sciences of the United States of America. 2021, 118 (10), 1-12.en_US
dc.identifier.issn0027-8424
dc.identifier.urihttps://hdl.handle.net/11250/2992229
dc.description.abstractThe primary task of a spermatozoon is to deliver its nuclear payload to the egg to form the next-generation zygote. With polyandry repeatedly evolving in the animal kingdom, however, sperm competition has become widespread, with the highest known intensities occurring in fish. Yet, the molecular controls regulating spermatozoon swimming performance in these organisms are largely unknown. Here, we show that the kinematic properties of postactivated piscine spermatozoa are regulated through a conserved trafficking mechanism whereby a peroxiporin ortholog of mammalian aquaporin-8 (Aqp8bb) is inserted into the inner mitochondrial membrane to facilitate H2O2 efflux in order to maintain ATP production. In teleosts from more ancestral lineages, such as the zebrafish (Danio rerio) and the Atlantic salmon (Salmo salar), in which spermatozoa are activated in freshwater, an intracellular Ca2+-signaling directly regulates this mechanism through monophosphorylation of the Aqp8bb N terminus. In contrast, in more recently evolved marine teleosts, such the gilthead seabream (Sparus aurata), in which spermatozoa activation occurs in seawater, a cross-talk between Ca2+- and oxidative stress-activated pathways generate a multiplier regulation of channel trafficking via dual N-terminal phosphorylation. These findings reveal that teleost spermatozoa evolved increasingly sophisticated detoxification pathways to maintain swimming performance under a high osmotic stress, and provide insight into molecular traits that are advantageous for postcopulatory sexual selection.en_US
dc.language.isoengen_US
dc.titleA multiplier peroxiporin signal transduction pathway powers piscine spermatozoaen_US
dc.typePeer revieweden_US
dc.typeJournal articleen_US
dc.description.versionpublishedVersionen_US
dc.source.pagenumber1-12en_US
dc.source.volume118en_US
dc.source.journalProceedings of the National Academy of Sciences of the United States of Americaen_US
dc.source.issue10en_US
dc.identifier.doi10.1073/pnas.2019346118
dc.identifier.cristin1931752
dc.relation.projectNorges forskningsråd: 254872en_US
dc.relation.projectNorges forskningsråd: 294768en_US
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode2


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