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dc.contributor.authorLie, Kai Kristoffer
dc.contributor.authorMeier, Sonnich
dc.contributor.authorSørhus, Elin
dc.contributor.authorEdvardsen, Rolf
dc.contributor.authorKarlsen, Ørjan
dc.contributor.authorOlsvik, Pål Asgeir
dc.date.accessioned2020-01-24T09:45:32Z
dc.date.available2020-01-24T09:45:32Z
dc.date.created2019-09-03T16:32:24Z
dc.date.issued2019
dc.identifier.citationFrontiers in Marine Science. 2019, 6:368 1-14.nb_NO
dc.identifier.issn2296-7745
dc.identifier.urihttp://hdl.handle.net/11250/2637766
dc.description.abstractThe aim of this study was to examine the impact of dispersed crude oil on retinoid metabolism and signaling in developing haddock larvae (Melanogrammus aeglefinus). Retinoids and its active metabolites are involved in the regulation of several developmental processes as cell differentiation, growth and limb patterning. Thus, disruption of retinoid signaling, especially during early developmental stages, may have detrimental effects on the organism. In the present study, crude oil exposure during embryonic development and early larvae development disrupted vitamin A signaling by affecting retinoid levels and genes involved in retinoid metabolism. The disruption of retinoid signaling was also evident when looking at the gene expression pattern at several time-points during and after exposure, demonstrating the complexity and temporal factor of retinoid signaling disruption. Exposure during the embryonic period (pre-hatch) resulted in reduced eye size and increased incidence of abnormal eye morphology. The observed changes in expression of retinoid metabolic genes related to the visual cycle indicates that there is a link between the modulated retinoid levels (all-trans retinoic acid and retinol) and increased incidence of abnormal eye development as a result of crude oil exposure. This is the first study to demonstrate disrupted retinoid signaling in fish following crude oil exposure at environmental relevant levels, giving novel insight in to the mechanism of toxicity.nb_NO
dc.language.isoengnb_NO
dc.titleOffshore crude oil disrupts retinoid signaling and eye development in larval Atlantic haddocknb_NO
dc.typeJournal articlenb_NO
dc.typePeer reviewednb_NO
dc.description.versionpublishedVersionnb_NO
dc.source.pagenumber1-14nb_NO
dc.source.volume6:368nb_NO
dc.source.journalFrontiers in Marine Sciencenb_NO
dc.identifier.doi10.3389/fmars.2019.00368
dc.identifier.cristin1721153
dc.relation.projectNorges forskningsråd: 234367nb_NO
dc.relation.projectNorges forskningsråd: 267829nb_NO
cristin.unitcode7431,32,0,0
cristin.unitcode7431,18,0,0
cristin.unitcode7431,24,0,0
cristin.unitnameTrygt fôr
cristin.unitnameMiljøkjemi
cristin.unitnameReproduksjon og utvikl.biologi
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1


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