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dc.contributor.authorSørensen, Lisbet
dc.contributor.authorHansen, Bjørn Henrik
dc.contributor.authorFarkas, Julia
dc.contributor.authorDonald, Carey
dc.contributor.authorRobson, William
dc.contributor.authorTonkin, Andrew
dc.contributor.authorMeier, Sonnich
dc.contributor.authorRowland, Steven J
dc.date.accessioned2019-06-12T11:40:55Z
dc.date.available2019-06-12T11:40:55Z
dc.date.created2019-05-14T11:24:02Z
dc.date.issued2019
dc.identifier.citationEnvironmental Pollution. 2019, 251 212-220.nb_NO
dc.identifier.issn0269-7491
dc.identifier.urihttp://hdl.handle.net/11250/2600614
dc.description.abstractA multitude of recent studies have documented the detrimental effects of crude oil exposure on early life stages of fish, including larvae and embryos. While polycyclic aromatic hydrocarbons (PAHs), particularly alkyl PAHs, are often considered the main cause of observed toxic effects, other crude oil derived organic compounds are usually overlooked. In the current study, comprehensive two-dimensional gas chromatography coupled to mass spectrometry was applied to investigate the body burden of a wide range of petrogenic compounds in Atlantic haddock (Melanogrammus aeglefinus) and cod (Gadus morhua) embryos that had been exposed to sublethal doses of dispersed crude oil. Several groups of alkylated monoaromatic compounds (e.g. alkyl tetralins, indanes and alkyl benzenes), as well as highly alkylated PAHs, were found to accumulate in the fish embryos upon crude oil exposure. To investigate the toxicity of the monoaromatic compounds, two models (1-isopropyl-4-methyltetralin and 1-isopropyl-4-methylindane) were synthesized and shown to bioaccumulate and cause delayed hatching in developing embryos. Minor developmental effects, including craniofacial and jaw deformations and pericardial edemas, were also observed at the highest studied concentrations of the alkylindane.nb_NO
dc.language.isoengnb_NO
dc.titleAccumulation and toxicity of monoaromatic petroleum hydrocarbons in early life stages of cod and haddocknb_NO
dc.typeJournal articlenb_NO
dc.typePeer reviewednb_NO
dc.description.versionacceptedVersionnb_NO
dc.source.pagenumber212-220nb_NO
dc.source.volume251nb_NO
dc.source.journalEnvironmental Pollutionnb_NO
dc.identifier.doi10.1016/j.envpol.2019.04.126
dc.identifier.cristin1697718
cristin.unitcode7431,18,0,0
cristin.unitnameMiljøkjemi
cristin.ispublishedtrue
cristin.fulltextpostprint
cristin.qualitycode1


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