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dc.contributor.authorFinn, Roderick Nigel
dc.contributor.authorChauvigné, Francois
dc.contributor.authorStavang, Jon Anders
dc.contributor.authorBelles, Xavier
dc.contributor.authorCerdà, Joan
dc.date.accessioned2015-12-22T10:34:40Z
dc.date.accessioned2016-01-20T08:46:51Z
dc.date.available2015-12-22T10:34:40Z
dc.date.available2016-01-20T08:46:51Z
dc.date.issued2015-06-12
dc.identifier.citationNature Communications 2015, 6:7814nb_NO
dc.identifier.issn2041-1723
dc.identifier.urihttp://hdl.handle.net/11250/2374272
dc.description-nb_NO
dc.description.abstractTransmembrane glycerol transport is typically facilitated by aquaglyceroporins in Prokaryota and Eukaryota. In holometabolan insects however, aquaglyceroporins are absent, yet several species possess polyol permeable aquaporins. It thus remains unknown how glycerol transport evolved in the Holometabola. By combining phylogenetic and functional studies, here we show that a more efficient form of glycerol transporter related to the water-selective channel AQP4 specifically evolved and multiplied in the insect lineage, resulting in the replacement of the ancestral branch of aquaglyceroporins in holometabolan insects. To recapitulate this evolutionary process, we generate specific mutants in distantly related insect aquaporins and human AQP4 and show that a single mutation in the selectivity filter converted a water-selective channel into a glycerol transporter at the root of the crown clade of hexapod insects. Integration of phanerozoic climate models suggests that these events were associated with the emergence of complete metamorphosis and the unparalleled radiation of insects.nb_NO
dc.language.isoengnb_NO
dc.publisherMacmillan Publishers Limitednb_NO
dc.rightsNavngivelse-DelPåSammeVilkår 3.0 Norge*
dc.rights.urihttp://creativecommons.org/licenses/by-sa/3.0/no/*
dc.titleInsect glycerol transporters evolved by functional co-option and gene replacementnb_NO
dc.typeJournal articlenb_NO
dc.typePeer reviewednb_NO
dc.date.updated2015-12-22T10:34:40Z
dc.subject.nsiVDP::Matematikk og naturvitenskap: 400::Basale biofag: 470::Genetikk og genomikk: 474nb_NO
dc.subject.nsiVDP::Mathematics and natural scienses: 400::Basic biosciences: 470::Genetics and genomics: 474nb_NO
dc.source.pagenumber7 s.nb_NO
dc.source.volume6nb_NO
dc.source.journalNature Communicationsnb_NO
dc.identifier.doi10.1038/ncomms8814
dc.identifier.cristin1276070


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