• Hepatotoxic pyrrolizidine alkaloids induce DNA damage response in rat liver in a 28-day feeding study 

      Ebmeyer, Johanna; Rasinger, Josef; Hengstler, Jan G.; Schaudien, Dirk; Creutzenberg, Otto; Lampen, Alfonso; Braeuning, Albert; Hassel-Pras, Stefanie (Peer reviewed; Journal article, 2020)
      Pyrrolizidine alkaloids (PA) are secondary plant metabolites that occur as food and feed contaminants. Acute and subacute PA poisoning can lead to severe liver damage in humans and animals, comprising liver pain, hepatomegaly ...
    • Proteomic analysis of hepatic effects of phenobarbital in mice with humanized liver 

      Sprenger, Heike; Rasinger, Josef; Hammer, Helen; Naboulsi, Wael; Zabinsky, Elke; Planatscher, Hannes; Schwarz, Michael; Poetz, Oliver; Braeuning, Albert (Peer reviewed; Journal article, 2022)
      Activation of the constitutive androstane receptor (CAR) may induce adaptive but also adverse effects in rodent liver, including the induction of drug-metabolizing enzymes, transient hepatocellular proliferation, and ...
    • Pyrrolizidine alkaloid-induced transcriptomic changes in rat lungs in a 28-day subacute feeding study 

      Buchmueller, Julia; Sprenger, Heike; Ebmeyer, Johanna; Rasinger, Josef; Creutzenberg, Otto; Schaudien, Dirk; Hengstler, Jan G.; Guenther, Georgia; Braeuning, Albert; Hessel-Pras, Stefanie (Peer reviewed; Journal article, 2021)
      Pyrrolizidine alkaloids (PAs) are secondary plant metabolites synthesized by a wide range of plants as protection against herbivores. These toxins are found worldwide and pose a threat to human health. PAs induce acute ...