Browsing Brage IMR by Author "Sprenger, Heike"

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    • Proteomic analysis of hepatic effects of phenobarbital in mice with humanized liver 

      Sprenger, Heike; Rasinger, Josef; Hammer, Helen; Naboulsi, Wael; Zabinsky, Elke; Planatscher, Hannes; Schwarz, Michael; Poetz, Oliver; Braeuning, Albert (Peer reviewed; Journal article, 2022)
      Activation of the constitutive androstane receptor (CAR) may induce adaptive but also adverse effects in rodent liver, including the induction of drug-metabolizing enzymes, transient hepatocellular proliferation, and ...

    • Pyrrolizidine alkaloid-induced transcriptomic changes in rat lungs in a 28-day subacute feeding study 

      Buchmueller, Julia; Sprenger, Heike; Ebmeyer, Johanna; Rasinger, Josef; Creutzenberg, Otto; Schaudien, Dirk; Hengstler, Jan G.; Guenther, Georgia; Braeuning, Albert; Hessel-Pras, Stefanie (Peer reviewed; Journal article, 2021)
      Pyrrolizidine alkaloids (PAs) are secondary plant metabolites synthesized by a wide range of plants as protection against herbivores. These toxins are found worldwide and pose a threat to human health. PAs induce acute ...