• Crude oil exposures reveal roles for intracellular calcium cycling in haddock craniofacial and cardiac development 

      Sørhus, Elin; Incardona, John P.; Karlsen, Ørjan; Linbo, Tiffany; Sørensen, Lisbet; Nordtug, Trond; van der Meeren, Terje; Thorsen, Anders; Thorbjørnsen, Maja; Jentoft, Sissel; Edvardsen, Rolf; Meier, Sonnich (Journal article; Peer reviewed, 2016-08-10)
      Recent studies have shown that crude oil exposure affects cardiac development in fish by disrupting excitation-contraction (EC) coupling. We previously found that eggs of Atlantic haddock (Melanogrammus aeglefinus) bind ...
    • Genomic architecture of haddock (Melanogrammus aeglefinus) shows expansions of innate immune genes and short tandem repeats 

      Tørresen, Ole K.; Brieuc, Marine Servane; Solbakken, Monica Hongrø; Sørhus, Elin; Nederbragt, Alexander Johan; Jakobsen, Kjetill Sigurd; Meier, Sonnich; Edvardsen, Rolf; Jentoft, Sissel (Journal article; Peer reviewed, 2018)
      Increased availability of genome assemblies for non-model organisms has resulted in invaluable biological and genomic insight into numerous vertebrates, including teleosts. Sequencing of the Atlantic cod (Gadus morhua) ...
    • Novel adverse outcome pathways revealed by chemical genetics in a developing marine fish 

      Sørhus, Elin; Incardona, John P.; Furmanek, Tomasz; Goetz, Giles W.; Scholz, Nathaniel; Meier, Sonnich; Edvardsen, Rolf; Jentoft, Sissel (Peer reviewed; Journal article, 2017)
      Crude oil spills are a worldwide ocean conservation threat. Fish are particularly vulnerable to the oiling of spawning habitats, and crude oil causes severe abnormalities in embryos and larvae. However, the underlying ...
    • Offshore crude oil disrupts retinoid signaling and eye development in larval Atlantic haddock 

      Lie, Kai Kristoffer; Meier, Sonnich; Sørhus, Elin; Edvardsen, Rolf; Karlsen, Ørjan; Olsvik, Pål Asgeir (Journal article; Peer reviewed, 2019)
      The aim of this study was to examine the impact of dispersed crude oil on retinoid metabolism and signaling in developing haddock larvae (Melanogrammus aeglefinus). Retinoids and its active metabolites are involved in the ...
    • Oil droplet fouling and differential toxicokinetics of polycyclic aromatic hydrocarbons in embryos of Atlantic haddock and cod 

      Sørensen, Lisbet; Sørhus, Elin; Nordtug, Trond; Incardona, John P.; Linbo, Tiffany; Giovanetti, Laura; Karlsen, Ørjan; Meier, Sonnich (Peer reviewed; Journal article, 2017)
      The impact of crude oil pollution on early life stages (ELS) of fish, including larvae and embryos, has received considerable attention in recent years. Of the organic components present in crude oil, polycyclic aromatic ...
    • Polyaromatic hydrocarbons in pollution: a heart-breaking matter 

      Marris, Charlotte; Kompella, Shiva N.; Miller, Mark M.; Incardona, John P.; Brette, Fabien; Hancox, Jules C.; Sørhus, Elin; Shiels, Holly A. (Journal article; Peer reviewed, 2019)
      Air pollution is associated with detrimental effects on human health, including decreased cardiovascular function. However, the causative mechanisms behind these effects have yet to be fully elucidated. Here we review the ...
    • Sex differentiation in Atlantic cod (Gadus morhua L.): morphological and gene expression studies 

      Haugen, Trine; Almeida, Fernanda F. L.; Andersson, Eva; Bogerd, Jan; Male, Rune; Skaar, Katrine S.; Schulz, Rüdiger W.; Sørhus, Elin; Wijgerde, Tim; Taranger, Geir Lasse (Journal article; Peer reviewed, 2012-06-18)
      Background In differentiated gonochoristic species, a bipotential gonad develops into an ovary or testis during sex differentiation. Knowledge about this process is necessary to improve methods for masculinizing genetically ...
    • Unexpected Interaction with Dispersed Crude Oil Droplets Drives Severe Toxicity in Atlantic Haddock Embryos 

      Sørhus, Elin; Edvardsen, Rolf B.; Karlsen, Ørjan; Nordtug, Trond; van der Meeren, Terje; Thorsen, Anders; Harman, Christopher; Jentoft, Sissel; Meier, Sonnich (Journal article; Peer reviewed, 2015-04-29)
      The toxicity resulting from exposure to oil droplets in marine fish embryos and larvae is still subject for debate. The most detailed studies have investigated the effects of water-dissolved components of crude oil in water ...
    • Vgll3 and the Hippo pathway are regulated in Sertoli cells upon entry and during puberty in Atlantic salmon testis 

      Kjærner-Semb, Erik Nordtorp; Ayllon, Fernando; Kleppe, Lene; Sørhus, Elin; Skaftnesmo, Kai Ove; Furmanek, Tomasz; Segafredo, Frida Thyri; Thorsen, Anders; Fjelldal, Per Gunnar; Hansen, Tom Johnny; Taranger, Geir Lasse; Andersson, Eva; Schulz, Rüdiger W.; Wargelius, Anna; Edvardsen, Rolf (Journal article; Peer reviewed, 2018)
      Vgll3 is linked to age at maturity in Atlantic salmon (Salmo salar). However, the molecular mechanisms involving Vgll3 in controlling timing of puberty as well as relevant tissue and cell types are currently unknown. Vgll3 ...