• Adipose MDM2 regulates systemic insulin sensitivity 

      Hallenborg, Philip; Jensen, Benjamin Anderschou Holbech; Fjære, Even; Petersen, Rasmus Koefoed; Belmaâti, Mohammed-Samir; Rasmussen, Sarah Søndergård; Gunnarsson, Jon Petur; Lauritzen, Pernille; Cheng, Kenneth King Yip; Hermansson, Martin; Sonne, Si Brask; Ejsing, Christer S.; Xu, Aimin; Kratchmarova, Irina; Krüger, Marcus; Madsen, Lise; Kristiansen, Karsten; Blagoev, Blagoy (Peer reviewed; Journal article, 2021)
      The intimate association between obesity and type II diabetes urges for a deeper understanding of adipocyte function. We and others have previously delineated a role for the tumor suppressor p53 in adipocyte biology. Here, ...
    • Anti-sea lice agents in Norwegian aquaculture; surveillance, treatment trends and possible implications for food safety 

      Hannisdal, Rita; Nøstbakken, Ole Jakob; Hove, Helge Torbjørn; Madsen, Lise; Horsberg, Tor Einar; Lunestad, Bjørn Tore (Peer reviewed; Journal article, 2020)
      Sea lice are a major challenge for the Norwegian aquaculture, and to cope with sea lice infections, several physical, biological and chemical treatments are applied. This study presents data on the use of anti-sea lice ...
    • A catalog of microbial genes from the bovine rumen unveils a specialized and diverse biomass-degrading environment 

      Li, Junhua; Zhong, Huanzi; Ramayo-Caldas, Yuliaxis; Terrapon, Nicolas; Lombard, Vincent; Potocki-Veronese, Gabrielle; Estellé, Jordi; Popova, Milka; Yang, Ziyi; Zhang, Hui; Li, Fang; Tang, Shanmei; Yang, Fangming; Chen, Weineng; Chen, Bing; Li, Jiyang; Guo, Jing; Martin, Cécile; Maguin, Emmanuelle; Xu, Xun; Yang, Huanming; Wang, Jian; Madsen, Lise; Kristiansen, Karsten; Henrissat, Bernard; Ehrlich, Stanislav D; Morgavi, Diego P (Peer reviewed; Journal article, 2020)
      Background The rumen microbiota provides essential services to its host and, through its role in ruminant production, contributes to human nutrition and food security. A thorough knowledge of the genetic potential of rumen ...
    • Co-diversification of an intestinal Mycoplasma and its salmonid host 

      Rasmussen, Jacob A.; Kiilerich, Pia; Madhun, Abdullah Sami; Waagbø, Rune; Lock, Erik Jan Robert; Madsen, Lise; Gilbert, Marcus Thomas Pius; Kristiansen, Karsten; Limborg, Morten T. (Peer reviewed; Journal article, 2023)
      Understanding the evolutionary relationships between a host and its intestinal resident bacteria can transform how we understand adaptive phenotypic traits. The interplay between hosts and their resident bacteria inevitably ...
    • Co-occurrence of contaminants in marine fish from the North East Atlantic Ocean: Implications for human risk assessment 

      Ho, Quang Tri; Bank, Michael; Mahjour Azad, Atabak; Nilsen, Bente Merete; Frantzen, Sylvia; Boitsov, Stepan; Måge, Amund; Kögel, Tanja; Sanden, Monica; Frøyland, Livar; Hannisdal, Rita; Hove, Helge Torbjørn; Lundebye, Anne-Katrine; Nøstbakken, Ole Jakob; Madsen, Lise (Peer reviewed; Journal article, 2021)
      Marine fish from the North East Atlantic Ocean (NEAO) are nutrient rich and considered a valuable economic resource. However, marine fish are also a major dietary source of several contaminants, including persistent organic ...
    • Commercially available kelp and seaweed products – valuable iodine source or risk of excess intake? 

      Aakre, Inger; Solli, Dina Doblaug; Markhus, Maria Wik; Mæhre, Hanne K; Dahl, Lisbeth; Henjum, Sigrun; Alexander, Jan; Korneliussen, Patrick-Andre; Madsen, Lise; Kjellevold, Marian (Peer reviewed; Journal article, 2021)
      Background: Seaweeds and kelps, also known as macroalgae, have long been common in the East-Asian diet. During recent years, macroalgae have entered the global food market, and a variety of macroalgae products are now ...
    • Congener-specific accumulation of persistent organic pollutants in marine fish from the Northeast Atlantic Ocean 

      Ho, Quang Tri; Frantzen, Sylvia; Nilsen, Bente Merete; Nøstbakken, Ole Jakob; Mahjour Azad, Atabak; Duinker, Arne; Madsen, Lise; Bank, Michael (Peer reviewed; Journal article, 2023)
      Bioaccumulation of persistent organic pollutants (POPs) in marine fish may pose a health risk to human consumers. Using data from ∼8400 individuals of 15 fish species collected in the North-East Atlantic Ocean (NEAO), we ...
    • CRISPR/cascade 9-mediated genome editing-challenges and opportunities 

      Roy, Bhaskar; Zhao, Jing; Yang, Chao; Luo, Wen; Xiong, Teng; Li, Yong; Fang, Xiaodong; Gao, Guanjun; Singh, Chabungbam O; Madsen, Lise; Zhou, Yong; Kristiansen, Karsten (Journal article; Peer reviewed, 2018)
      Clustered Regularly Interspaced Palindromic Repeats (CRISPR) and Cascade 9 (also known as Cas9, CRISPR associated protein 9) confer protection against invading viruses or plasmids. The CRISPR/Cascade 9 system constitutes ...
    • Dietary Proteins, Brown Fat, and Adiposity 

      Madsen, Lise; Myrmel, Lene Secher; Fjære, Even; Øyen, Jannike; Kristiansen, Karsten (Journal article; Peer reviewed, 2018)
      High protein diets have become popular for body weight maintenance and weight loss despite controversies regarding efficacy and safety. Although both weight gain and weight loss are determined by energy consumption and ...
    • Dietary selenomethionine reduce mercury tissue levels and modulate methylmercury induced proteomic and transcriptomic alterations in hippocampi of adolescent BALB/c mice 

      Mellingen, Ragnhild Marie; Myrmel, Lene Secher; Rasinger, Josef; Lie, Kai Kristoffer; Bernhard, Annette; Madsen, Lise; Nøstbakken, Ole Jakob (Peer reviewed; Journal article, 2022)
      Methylmercury (MeHg) is a well-known environmental contaminant, particularly harmful to the developing brain. The main human dietary exposure to MeHg occurs through seafood consumption. However, seafood also contains several ...
    • Differences in nutrient and undesirable substance concentrations in Maurolicus muelleri across the Bay of Biscay, Norwegian fjords, and the North Sea 

      Zhu, Yiou; Mahjour Azad, Atabak; Kjellevold, Marian; Bald, Carlos; Iñarra, Bruno; Alvarez, Paula; Boyra, Guillermo; Berntssen, Marc HG; Madsen, Lise; Wiech, Martin (Peer reviewed; Journal article, 2023)
      We are having pressing issues of global food insecurity and malnutrition. Mesopelagic communities in the North Atlantic have been estimated to have high biomasses of organisms. Some of these low-trophic organisms are known ...
    • Distinct gut metagenomics and metaproteomics signatures in prediabetics and treatment-naive type 2 diabetics 

      Zhong, Huanzi; Ren, Huahui; Lu, Yan; Fang, Chao; Hou, Guixue; Yang, Ziyi; Chen, Bing; Yang, Fangming; Zhao, Yue; Shi, Zhun; Zhou, Baojin; Wu, Jiegen; Zou, Hua; Zi, Jin; Chen, Jiayu; Bao, Xiao; Hu, Yihe; Gao, Yan; Zhang, Jun; Xu, Xun; Hou, Yong; Yang, Huanming; Wang, Jian; Liu, Siqi; Jia, Huijue; Madsen, Lise; Brix, Susanne; Kristiansen, Karsten; Liu, Fang; Li, Junhua (Peer reviewed; Journal article, 2019)
      Background The gut microbiota plays important roles in modulating host metabolism. Previous studies have demonstrated differences in the gut microbiome of T2D and prediabetic individuals compared to healthy individuals, ...
    • Effects of exercise and dietary protein sources on adiposity and insulin sensitivity in obese mice 

      Fjære, Even; Myrmel, Lene Secher; Lützhøft, Ditte Olsen; Andersen, Hanne; Holm, Jacob Bak; Kiilerich, Pia; Hannisdal, Rita; Liaset, Bjørn; Kristiansen, Karsten; Madsen, Lise (Journal article; Peer reviewed, 2019)
      Low-fat diets and exercise are generally assumed to ameliorate obesity-related metabolic dysfunctions, but the importance of exercise vs. dietary changes is debated. Male C57BL/6J mice were fed a high-fat/high-sucrose ...
    • Effects of frozen storage on phospholipid content in atlantic cod fillets and the influence on diet-induced obesity in mice 

      Fauske, Kristin Røen; Bernhard, Annette; Fjære, Even; Myrmel, Lene Secher; Frøyland, Livar; Kristiansen, Karsten; Liaset, Bjørn; Madsen, Lise (Peer reviewed; Journal article, 2018)
    • Effects of geography and species variation on selenium and mercury molar ratios in Northeast Atlantic marine fish communities 

      Mahjour Azad, Atabak; Frantzen, Sylvia; Bank, Michael; Nilsen, Bente Merete; Duinker, Arne; Madsen, Lise; Måge, Amund (Journal article; Peer reviewed, 2019)
      Methylmercury (MeHg) is a potent neurotoxin that bioaccumulates in seafood. Co-occurrence of selenium (Se) may affect the bioavailability and toxicity of MeHg in organisms. Here we report the concentrations of total mercury ...
    • An Expanded Gene Catalog of Mouse Gut Metagenomes 

      Zhu, Jiahui; Ren, Huahui; Zhong, Huanzi; Li, Xiaoping; Zou, Yuanqiang; Han, Mo; Li, Minli; Madsen, Lise; Kristiansen, Karsten; Xiao, Liang (Peer reviewed; Journal article, 2021)
      High-quality and comprehensive reference gene catalogs are essential for metagenomic research. The rather low diversity of samples used to construct existing catalogs of the mouse gut metagenome limits the numbers of ...
    • Factors influencing risk assessments of brominated flame-retardants; evidence based on seafood from the North East Atlantic Ocean 

      Nøstbakken, Ole Jakob; Duinker, Arne; Rasinger, Josef Daniel; Nilsen, Bente Merete; Sanden, Monica; Frantzen, Sylvia; Hove, Helge Torbjørn; Lundebye, Anne-Katrine; Berntssen, Marc; Hannisdal, Rita; Madsen, Lise; Måge, Amund (Journal article; Peer reviewed, 2018)
      Brominated flame-retardants (BFRs) such as polybrominated diphenyl ethers (PBDE) and hexabromocyclododecane (HBCD) are considered hazardous to human health. Due to their persistence, they are still present in the environment ...
    • Fish-derived proteins and their potential to improve human health 

      Dale, Hanna Fjeldheim; Madsen, Lise; Lied, Gülen Arslan (Journal article; Peer reviewed, 2019)
      Emerging evidence from studies evaluating the effect of lean fish consumption in humans suggests that proteins from fish have several beneficial metabolic effects. Rest, or waste, material from the fishing industry contains ...
    • Iodine Bioavailability and Accumulation of Arsenic and Cadmium in Rats Fed Sugar Kelp (Saccharina latissima) 

      Fjære, Even; Poulsen, Rikke; Duinker, Arne; Liaset, Bjørn; Hansen, Martin; Madsen, Lise; Myrmel, Lene Secher (Peer reviewed; Journal article, 2022)
      Suboptimal iodine status is a prominent public health issue in several European coun-tries. Brown algae have a high iodine content that, upon intake, may exceed the recommended dietary intake level, but iodine bioavailability ...
    • Iodine status and thyroid function in a group of seaweed consumers in Norway 

      Aakre, Inger; Evensen, Lidunn Tveito; Kjellevold, Marian; Dahl, Lisbeth; Henjum, Sigrun; Alexander, Jan; Madsen, Lise; Markhus, Maria Wik (Peer reviewed; Journal article, 2020)
      Seaweeds, or macroalgae, may be a good dietary iodine source but also a source of excessive iodine intake. The main aim in this study was to describe the iodine status and thyroid function in a group of macroalgae consumers. ...