• Atlantic salmon populations reveal adaptive divergence of immune related genes - A duplicated genome under selection 

      Kjærner-Semb, Erik Nordtorp; Ayllon, Fernando; Furmanek, Tomasz; Wennevik, Vidar; Dahle, Geir; Niemelä, Eero; Ozerov, Mikhail; Vähä, Juha-Pekka; Glover, Kevin; Rubin, Carl J.; Wargelius, Anna; Edvardsen, Rolf (Journal article, 2016)
    • Comparison of anadromous and landlocked Atlantic salmon genomes reveals signatures of parallel and relaxed selection across the Northern Hemisphere 

      Kjærner-Semb, Erik Nordtorp; Edvardsen, Rolf Brudvik; Ayllon, Fernando; Vogelsang, Petra; Furmanek, Tomasz; Rubin, Carl-Johan; Veselov, Alexey E.; Nilsen, Tom Ole; McCormick, Stephen D.; Primmer, Craig R.; Wargelius, Anna (Peer reviewed; Journal article, 2020)
      Most Atlantic salmon (Salmo salar L.) populations follow an anadromous life cycle, spending early life in freshwater, migrating to the sea for feeding, and returning to rivers to spawn. At the end of the last ice age ~10,000 ...
    • Full production cycle performance of gene-edited, sterile Atlantic salmon - growth, smoltification, welfare indicators and fillet composition 

      Kleppe, Lene; Fjelldal, Per Gunnar; Andersson, Eva; Hansen, Tom Johnny; Sanden, Monica; Bruvik, Aina; Skaftnesmo, Kai Ove; Furmanek, Tomasz; Kjærner-Semb, Erik Nordtorp; Crespo, Diego; Flavell, Simon; Pedersen, Audun Østby; Vogelsang, Petra; Torsvik, Anja; Kvestad, Karen Anita; Olausson, Sara; Norberg, Birgitta; Schulz, Rüdiger W.; Bogerd, J.; Santi, N.; Edvardsen, Rolf Brudvik; Wargelius, Anna (Peer reviewed; Journal article, 2022)
      Using germ cell-free (GCF), sterile, dnd-knockout salmon for farming could solve the problems associated with precocious maturation and genetic introgression of farmed breeds into wild populations. However, prior to using ...
    • Heterochiasmy and the establishment of gsdf as a novel sex determining gene in Atlantic halibut 

      Edvardsen, Rolf Brudvik; Wallerman, Ola; Furmanek, Tomasz; Kleppe, Lene; Jern, Patric; Wallberg, Andreas; Kjærner-Semb, Erik Nordtorp; Mæhle, Stig; Olausson, Sara; Sundström, Elisabeth; Harboe, Torstein; Mangor-Jensen, Ragnfrid; Drønen, Margareth Møgster; Perrichon, Prescilla; Norberg, Birgitta; Rubin, Carl-Johan (Peer reviewed; Journal article, 2022)
      Atlantic Halibut (Hippoglossus hippoglossus) has a X/Y genetic sex determination system, but the sex determining factor is not known. We produced a high-quality genome assembly from a male and identified parts of chromosome ...
    • In vivo CRISPR/LbCas12a-mediated knock-in and knock-out in Atlantic salmon (Salmo salar L.) 

      Raudstein, Mari Torsdotter; Kjærner-Semb, Erik Nordtorp; Barvik, Morten; Broll, Silje; Straume, Anne Hege; Edvardsen, Rolf Brudvik (Peer reviewed; Journal article, 2023)
      Genome editing using the CRISPR/Cas system offers the potential to enhance current breeding programs and introduce desirable genetic traits, including disease resistance, in salmon aquaculture. Several nucleases are available ...
    • Indel locations are determined by template polarity in highly efficient in vivo CRISPR/Cas9- mediated HDR in Atlantic salmon 

      Straume, Anne Hege; Kjærner-Semb, Erik Nordtorp; Skaftnesmo, Kai Ove; guralp, hilal; Kleppe, Lene; Wargelius, Anna; Edvardsen, Rolf Brudvik (Peer reviewed; Journal article, 2020)
      Precise gene editing such as CRISPR/Cas9-mediated homology directed repair (HDR) can increase our understanding of gene function and improve traits of importance for aquaculture. This fine-tuned technology has not been ...
    • Pituitary Gonadotropin Gene Expression During Induced Onset of Postsmolt Maturation in Male Atlantic Salmon: In Vivo and Tissue Culture Studies 

      Crespo, Diego; Skaftnesmo, Kai Ove; Kjærner-Semb, Erik Nordtorp; Yilmaz, Ozlem; Norberg, Birgitta; Olausson, Sara; Vogelsang, Petra; Bogerd, Jan; Kleppe, Lene; Edvardsen, Rolf Brudvik; Andersson, Eva; Wargelius, Anna; Hansen, Tom Johnny; Fjelldal, Per Gunnar; Schulz, Rüdiger W. (Peer reviewed; Journal article, 2022)
      Precocious male maturation causes reduced welfare and increased production costs in Atlantic salmon (Salmo salar) aquaculture. The pituitary produces and releases follicle-stimulating hormone (Fsh), the gonadotropin ...
    • Rescue of germ cells in dnd crispant embryos opens the possibility to produce inherited sterility in Atlantic salmon 

      Guralp, Hilal; Skaftnesmo, Kai Ove; Kjærner-Semb, Erik Nordtorp; Straume, Anne Hege; Kleppe, Lene; Schulz, Rüdiger W.; Edvardsen, Rolf Brudvik; Wargelius, Anna (Peer reviewed; Journal article, 2020)
      Genetic introgression of escaped farmed Atlantic salmon (Salmo salar) into wild populations is a major environmental concern for the salmon aquaculture industry. Using sterile fish in commercial aquaculture operations is, ...
    • Single nucleotide replacement in the Atlantic salmon genome using CRISPR/Cas9 and asymmetrical oligonucleotide donors 

      Straume, Anne Hege; Kjærner-Semb, Erik Nordtorp; Skaftnesmo, Kai Ove; Guralp, Hilal; Lillico, Simon; Wargelius, Anna; Edvardsen, Rolf Brudvik (Peer reviewed; Journal article, 2021)
      New breeding technologies (NBT) using CRISPR/Cas9-induced homology directed repair (HDR) has the potential to expedite genetic improvement in aquaculture. The long generation time in Atlantic salmon makes breeding an ...
    • The influence of vgll3 genotypes on sea age at maturity is altered in farmed mowi strain Atlantic salmon 

      Ayllon, Fernando; Solberg, Monica Favnebøe; Glover, Kevin; Mohammadi, Faezeh; Kjærner-Semb, Erik Nordtorp; Fjelldal, Per Gunnar; Andersson, Eva; Hansen, Tom Johnny; Edvardsen, Rolf; Wargelius, Anna (Journal article; Peer reviewed, 2019)
      Background: In Atlantic salmon in the wild, age at maturity is strongly influenced by the vgll3 locus. Under farming conditions, light, temperature and feeding regimes are known significantly advance or delay age at ...
    • The vgll3 Locus Controls Age at Maturity in Wild and Domesticated Atlantic Salmon(Salmo salar L.) Males 

      Ayllon, Fernando; Kjærner-Semb, Erik Nordtorp; Furmanek, Tomasz; Wennevik, Vidar; Solberg, Monica Favnebøe; Dahle, Geir; Taranger, Geir Lasse; Glover, Kevin; Sällman Almèn, Markus; Rubin, Carl J.; Edvardsen, Rolf; Wargelius, Anna (Journal article; Peer reviewed, 2015-11-09)
      Wild and domesticated Atlantic salmon males display large variation for sea age at sexual maturation, which varies between 1–5 years. Previous studies have uncovered a genetic predisposition for variation of age at maturity ...
    • Vgll3 and the Hippo pathway are regulated in Sertoli cells upon entry and during puberty in Atlantic salmon testis 

      Kjærner-Semb, Erik Nordtorp; Ayllon, Fernando; Kleppe, Lene; Sørhus, Elin; Skaftnesmo, Kai Ove; Furmanek, Tomasz; Segafredo, Frida Thyri; Thorsen, Anders; Fjelldal, Per Gunnar; Hansen, Tom Johnny; Taranger, Geir Lasse; Andersson, Eva; Schulz, Rüdiger W.; Wargelius, Anna; Edvardsen, Rolf (Journal article; Peer reviewed, 2018)
      Vgll3 is linked to age at maturity in Atlantic salmon (Salmo salar). However, the molecular mechanisms involving Vgll3 in controlling timing of puberty as well as relevant tissue and cell types are currently unknown. Vgll3 ...