Browsing Brage IMR by Author "Jakt, Lars Martin"

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Parental micronutrient deficiency distorts liver DNA methylation and expression of lipid genes associated with a fatty-liver-like phenotype in offspring

Skjærven, Kaja Helvik; Jakt, Lars Martin; Fernandes, Jorge Manuel de Oliveira; Dahl, John Arne; Adam, Anne-Catrin; Klughammer, Johanna; Bock, Christoph; Espe, Marit (Journal article; Peer reviewed, 2018)

Micronutrient status of parents can affect long term health of their progeny. Around 2 billion humans are affected by chronic micronutrient deficiency. In this study we use zebrafish as a model system to examine morphological, ...
Profiling DNA methylation patterns of zebrafish liver associated with parental high dietary arachidonic acid.

Adam, Anne-Catrin; Lie, Kai Kristoffer; Whatmore, Paul; Jakt, Lars Martin; Moren, Mari; Skjærven, Kaja Helvik (Journal article; Peer reviewed, 2019)

Diet has been shown to influence epigenetic key players, such as DNA methylation, which can regulate the gene expression potential in both parents and offspring. Diets enriched in omega-6 and deficient in omega-3 PUFAs ...