Browsing Brage IMR by Author "Fernandes, Jorge Manuel de Oliveira"
Now showing items 1-7 of 7
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The first mitochondrial 5-methylcytosine map in a non-model teleost (Oreochromis niloticus) reveals extensive strand-specific and non-CpG methylation
Nedoluzhko, Artem; Mjelle, Robin; Renström, Maria; Skjærven, Kaja Helvik; Piferrer, Francesc; Fernandes, Jorge Manuel de Oliveira (Peer reviewed; Journal article, 2021)DNA methylation is one of the main epigenetic mechanisms that regulate gene expression in a manner that depends on the genomic context and varies considerably across taxa. This DNA modification was first found in nuclear ... -
Metabolic and molecular signatures of improved growth in Atlantic salmon (Salmo salar) fed surplus levels of methionine, folic acid, vitamin B6 and B12 throughout smoltification.
Adam, Anne-Catrin; Saito, Takaya; Espe, Marit; Whatmore, Paul; Fernandes, Jorge Manuel de Oliveira; Vikeså, Vibeke; Skjærven, Kaja Helvik (Peer reviewed; Journal article, 2021)A moderate surplus of the 1C nutrients methionine, folic acid, vitamin B6 and B12 above dietary recommendations for Atlantic salmon has shown to improve growth and reduce hepatosomatic index in the on-growing salt water ... -
Micronutrient supplementation affects DNA methylation in male gonads with potential intergenerational epigenetic inheritance involving the embryonic development through glutamate receptor-associated genes
Saito, Takaya; Whatmore, Paul; Taylor, John F.; Fernandes, Jorge Manuel de Oliveira; Adam, Anne-Catrin; Tocher, Douglas R.; Espe, Marit; Skjærven, Kaja Helvik (Peer reviewed; Journal article, 2022)DNA methylation has an important role in intergenerational inheritance. An increasing number of studies have reported evidence of germline inheritance of DNA methylation induced by nutritional signals in mammals. Vitamins ... -
Micronutrient supplementation affects transcriptional and epigenetic regulation of lipid metabolism in a dose-dependent manner
Saito, Takaya; Whatmore, Paul; Taylor, John F.; Fernandes, Jorge Manuel de Oliveira; Adam, Anne-Catrin; Tocher, Douglas R.; Espe, Marit; Skjærven, Kaja Helvik (Peer reviewed; Journal article, 2020) -
Ocean warming shapes embryonic developmental prospects of the next generation in Atlantic cod
Skjærven, Kaja Helvik; Alix, Maud; Kleppe, Lene; Fernandes, Jorge Manuel de Oliveira; Whatmore, Paul; Nedoluzhko, Artem; Andersson, Eva; Kjesbu, Olav Sigurd (Peer reviewed; Journal article, 2024)Although early embryonic protein production relies exclusively on maternal molecules such as messenger RNAs (mRNAs) incorporated into ovarian follicles, knowledge about any thermally induced, intergenerational effects is ... -
One-carbon metabolism nutrients impact the interplay between DNA methylation and gene expression in liver, enhancing protein synthesis in Atlantic salmon
Saito, Takaya; Espe, Marit; Vikeså, Vibeke; Bock, Christoph; Thomsen, Tårn H.; Adam, Anne-Catrin; Fernandes, Jorge Manuel de Oliveira; Skjærven, Kaja Helvik (Peer reviewed; Journal article, 2024)Supplementation of one-carbon (1C) metabolism micronutrients, which include B-vitamins and methionine, is essential for the healthy growth and development of Atlantic salmon (Salmo salar). However, the recent shift towards ... -
Parental micronutrient deficiency distorts liver DNA methylation and expression of lipid genes associated with a fatty-liver-like phenotype in offspring
Skjærven, Kaja Helvik; Jakt, Lars Martin; Fernandes, Jorge Manuel de Oliveira; Dahl, John Arne; Adam, Anne-Catrin; Klughammer, Johanna; Bock, Christoph; Espe, Marit (Journal article; Peer reviewed, 2018)Micronutrient status of parents can affect long term health of their progeny. Around 2 billion humans are affected by chronic micronutrient deficiency. In this study we use zebrafish as a model system to examine morphological, ...