Browsing Brage IMR by Author "Edvardsen, Rolf Brudvik"

Now showing items 1-20 of 23

    • Autosomal sdY pseudogenes explain discordances between phenotypic sex and DNA marker for sex identification in Atlantic salmon 

      Ayllon, Fernando; Solberg, Monica Favnebøe; Besnier, Francois; Fjelldal, Per Gunnar; Hansen, Tom Johnny; Wargelius, Anna; Edvardsen, Rolf Brudvik; Glover, Kevin (Peer reviewed; Journal article, 2020)
      Despite the key role that sex-determination plays in evolutionary processes, it is still poorly understood in many species. In salmonids, which are among the best studied fishes, the master sex-determining gene sexually ...

    • Cardiac dysfunction affects eye development and vision by reducing supply of lipids in fish 

      Sørhus, Elin; Meier, Sonnich; Donald, Carey; Furmanek, Tomasz; Edvardsen, Rolf Brudvik; Lie, Kai Kristoffer (Peer reviewed; Journal article, 2021)
      Developing organisms are especially vulnerable to environmental stressors. Crude oil exposure in early life stages of fish result in multiple functional and developmental defects, including cardiac dysfunction and abnormal ...

    • Comparison of anadromous and landlocked Atlantic salmon genomes reveals signatures of parallel and relaxed selection across the Northern Hemisphere 

      Kjærner-Semb, Erik Nordtorp; Edvardsen, Rolf Brudvik; Ayllon, Fernando; Vogelsang, Petra; Furmanek, Tomasz; Rubin, Carl-Johan; Veselov, Alexey E.; Nilsen, Tom Ole; McCormick, Stephen D.; Primmer, Craig R.; Wargelius, Anna (Peer reviewed; Journal article, 2020)
      Most Atlantic salmon (Salmo salar L.) populations follow an anadromous life cycle, spending early life in freshwater, migrating to the sea for feeding, and returning to rivers to spawn. At the end of the last ice age ~10,000 ...

    • CRISPR/Cas9-mediated editing of Δ5 and Δ6 desaturases impairs Δ8-desaturation and docosahexaenoic acid synthesis in Atlantic salmon (Salmo salar L.) 

      Datsomor, Alex Kojo; Olsen, Rolf Erik; Madaro, Angelico; Bones, Atle M.; Edvardsen, Rolf Brudvik; Wargelius, Anna; Winge, Per (Journal article; Peer reviewed, 2019)
      The in vivo functions of Atlantic salmon fatty acyl desaturases (fads2), Δ6fads2-a, Δ6fads2-b, Δ6fads2-c and Δ5fads2 in long chain polyunsaturated fatty acid (LC-PUFA) synthesis in salmon and fish in general remains to be ...

    • Effect of diet on molecular relationships between Atlantic cod larval muscle growth dynamics, metabolism, and antioxidant defense system 

      Vo, Tu Anh; Galloway, Trina Falck; Arukwe, Augustine; Edvardsen, Rolf Brudvik; Hamre, Kristin; Karlsen, Ørjan; Rønnestad, Ivar; Kjørsvik, Elin (Peer reviewed; Journal article, 2022)
      We studied molecular effects (RNAseq and qPCR) of first feeding prey types (copepods or rotifers/Artemia) on skeletal muscle myogenesis and growth dynamics (proliferation, differentiation), metabolism (glycolysis, ...

    • Full production cycle performance of gene-edited, sterile Atlantic salmon - growth, smoltification, welfare indicators and fillet composition 

      Kleppe, Lene; Fjelldal, Per Gunnar; Andersson, Eva; Hansen, Tom Johnny; Sanden, Monica; Bruvik, Aina; Skaftnesmo, Kai Ove; Furmanek, Tomasz; Kjærner-Semb, Erik Nordtorp; Crespo, Diego; Flavell, Simon; Pedersen, Audun Østby; Vogelsang, Petra; Torsvik, Anja; Kvestad, Karen Anita; Olausson, Sara; Norberg, Birgitta; Schulz, Rüdiger W.; Bogerd, J.; Santi, N.; Edvardsen, Rolf Brudvik; Wargelius, Anna (Peer reviewed; Journal article, 2022)
      Using germ cell-free (GCF), sterile, dnd-knockout salmon for farming could solve the problems associated with precocious maturation and genetic introgression of farmed breeds into wild populations. However, prior to using ...

    • Genome editing in food and feed production – implications for risk assessment 

      Bodin, Johanna Eva; Thorstensen, Tage; Alsheikh, Muath K; Basic, Dean; Edvardsen, Rolf Brudvik; Dalen, Knut Tomas; das Neves, Carlos Gonçalo; Duale, Nur; Eklo, Ole Martin; Ergon, Åshild Gunilla; Jevnaker, Anne-Marthe Ganes; Hindar, Kjetil; Håvarstein, Leiv Sigve; Malmstrøm, Martin; Nielsen, Kaare Magne; Olsen, Siri Lie; Rueness, Eli Knispel; Sanden, Monica; Sipinen, Ville Erling; Vikse, Rose; von Krogh, Kristine; Våge, Dag Inge; Wargelius, Anna; Wendell, Micael; Yazdankhah, Siamak Pour; Alexander, Jan; Bruzell, Ellen Merete; Hemre, Gro Ingunn; Vandvik, Vigdis; Agdestein, Angelika; Elvevoll, Edel O.; Hessen, Dag Olav; Hofshagen, Merete; Husøy, Trine; Knutsen, Helle Katrine; Krogdahl, Åshild; Nilsen, Asbjørn Magne; Rafoss, Trond; Skjerdal, Olaug Taran; Steffensen, Inger-Lise Karin; Strand, Tor Arne; Velle, Gaute; Wasteson, Yngvild (Peer reviewed; Journal article, 2021)
      The Norwegian Scientific Committee for Food and Environment (VKM) initiated this work to examine the extent to which organisms developed by genome-editing technologies pose new challenges in terms of risk assessment. This ...

    • Genome editing in food and feed production – implications for risk assessment. Opinion of the Steering Committee of the Norwegian Scientific Committee for Food and Environment 

      Bodin, Johanna Eva; Thorstensen, Tage; Alsheikh, Muath; Basic, Dean; Edvardsen, Rolf Brudvik; Dalen, Knut Tomas; das Neves, Carlos Gonçalo; Duale, Nur; Eklo, Ole Martin; Ergon, Åshild Gunilla; Jevnaker, Anne-Marthe Ganes; Hindar, Kjetil; Håvarstein, Sigve; Malmstrøm, Martin; Nielsen, Kaare Magne; Olsen, Siri Lie; Rueness, Eli Knispel; Sanden, Monica; Sipinen, Ville Erling; Vikse, Rose; von Krogh, Kristine; Våge, Dag Inge; Wargelius, Anna Sofie Troedsson; Wendell, Per Hans Micael; Yazdankhah, Siamak Pour; Alexander, Jan; Bruzell, Ellen Merete; Hemre, Gro Ingunn; Vandvik, Vigdis; Agdestein, Angelika; Elvevoll, Edel O.; Hessen, Dag Olav; Hofshagen, Merete; Husøy, Trine; Knutsen, Helle Katrine; Krogdahl, Åshild; Nilsen, Asbjørn Magne; Rafoss, Trond; Skjerdal, Olaug Taran; Steffensen, Inger-Lise Karin; Strand, Tor Arne; Velle, Gaute; Wasteson, Yngvild (Peer reviewed; Journal article, 2021)

    • Genome editing in food and feed production – implications for risk assessment. Scientific Opinion of the Scientific Steering Committee of the Norwegian Scientific Committee for Food and Environment 

      Bodin, Johanna Eva; Thorstensen, Tage; Alsheikh, Muath K; Basic, Dean; Edvardsen, Rolf Brudvik; Dalen, Knut Tomas; Duale, Nur; Eklo, Ole Martin; Ergon, Åshild Gunilla; Jevnaker, Anne-Marthe Ganes; Hindar, Kjetil; Håvarstein, Leiv Sigve; Malmstrøm, Martin; Nielsen, Kaare Magne; Olsen, Siri Lie; Rueness, Eli Knispel; Sanden, Monica; Sipinen, Ville Erling; von Krogh, Kristine; Våge, Dag Inge; Wargelius, Anna; Wendell, Per Hans Micael; Yazdankhah, Siamak Pour; Alexander, Jan; Bruzell, Ellen Merete; Hemre, Gro Ingunn; Vandvik, Vigdis; Agdestein, Angelika; Elvevoll, Edel O.; Hessen, Dag Olav; Hofshagen, Merete; Husøy, Trine; Knutsen, Helle Katrine; Krogdahl, Åshild; Nilsen, Asbjørn Magne; Rafoss, Trond; Skjerdal, Olaug Taran; Steffensen, Inger-Lise Karin; Strand, Tor Arne; Velle, Gaute; Wasteson, Yngvild (Peer reviewed; Journal article, 2021)
      The Norwegian Scientific Committee for Food and Environment (VKM) initiated this work to examine the extent to which organisms developed by genome-editing technologies pose new challenges in terms of risk assessment. This ...

    • Heterochiasmy and the establishment of gsdf as a novel sex determining gene in Atlantic halibut 

      Edvardsen, Rolf Brudvik; Wallerman, Ola; Furmanek, Tomasz; Kleppe, Lene; Jern, Patric; Wallberg, Andreas; Kjærner-Semb, Erik Nordtorp; Mæhle, Stig; Olausson, Sara; Sundström, Elisabeth; Harboe, Torstein; Mangor-Jensen, Ragnfrid; Drønen, Margareth Møgster; Perrichon, Prescilla; Norberg, Birgitta; Rubin, Carl-Johan (Peer reviewed; Journal article, 2022)
      Atlantic Halibut (Hippoglossus hippoglossus) has a X/Y genetic sex determination system, but the sex determining factor is not known. We produced a high-quality genome assembly from a male and identified parts of chromosome ...

    • Impact of Antioxidant Feed and Growth Manipulation on the Redox Regulation of Atlantic Salmon Smolts 

      Yin, Peng; Bjørnsson, Bjørn Thrandur; Fjelldal, Per Gunnar; Saito, Takaya; Remø, Sofie C.; Edvardsen, Rolf Brudvik; Hansen, Tom Johnny; Sharma, Sandeep; Olsen, Rolf Erik; Hamre, Kristin (Peer reviewed; Journal article, 2022)
      Accumulating evidence indicates a close relationship between oxidative stress and growth rate in fish. However, the underlying mechanisms of this relationship remain unclear. This study evaluated the combined effect of ...

    • In vivo CRISPR/LbCas12a-mediated knock-in and knock-out in Atlantic salmon (Salmo salar L.) 

      Raudstein, Mari Torsdotter; Kjærner-Semb, Erik Nordtorp; Barvik, Morten; Broll, Silje; Straume, Anne Hege; Edvardsen, Rolf Brudvik (Peer reviewed; Journal article, 2023)
      Genome editing using the CRISPR/Cas system offers the potential to enhance current breeding programs and introduce desirable genetic traits, including disease resistance, in salmon aquaculture. Several nucleases are available ...

    • Indel locations are determined by template polarity in highly efficient in vivo CRISPR/Cas9- mediated HDR in Atlantic salmon 

      Straume, Anne Hege; Kjærner-Semb, Erik Nordtorp; Skaftnesmo, Kai Ove; guralp, hilal; Kleppe, Lene; Wargelius, Anna; Edvardsen, Rolf Brudvik (Peer reviewed; Journal article, 2020)
      Precise gene editing such as CRISPR/Cas9-mediated homology directed repair (HDR) can increase our understanding of gene function and improve traits of importance for aquaculture. This fine-tuned technology has not been ...

    • Loss of stra8 Increases Germ Cell Apoptosis but Is Still Compatible With Sperm Production in Atlantic Salmon (Salmo salar) 

      Skaftnesmo, Kai Ove; Crespo, Diego; Kleppe, Lene; Andersson, Eva; Edvardsen, Rolf Brudvik; Norberg, Birgitta; Fjelldal, Per Gunnar; Hansen, Tom Johnny; Schulz, Rüdiger W.; Wargelius, Anna (Peer reviewed; Journal article, 2021)
      Entering meiosis strictly depends on stimulated by retinoic acid 8 (Stra8) gene function in mammals. This gene is missing in a number of fish species, including medaka and zebrafish, but is present in the majority of fishes, ...

    • Microbial communities associated with the parasitic copepod Lepeophtheirus salmonis. 

      Dalvin, Sussie; Skaftnesmo, Kai Ove; Malde, Ketil; Glover, Kevin; Leong, Jong S; Koop, Ben F.; Edvardsen, Rolf Brudvik; Sandlund, Nina (Peer reviewed; Journal article, 2019)
      Lepeophtheirus salmonis is a naturally occurring marine parasite of salmonid fishes in the Northern hemisphere, and a major problem in salmonid aquaculture. In addition to the direct effects on host fish, L. salmonis may ...

    • Photoreception and transcriptomic response to light during early development of a teleost with a life cycle tightly controlled by seasonal changes in photoperiod 

      Eilertsen, Mariann; Dolan, David William Peter; Bolton, Charlotte M.; Karlsen, Rita; Davies, Wayne I.L.; Edvardsen, Rolf Brudvik; Furmanek, Tomasz; Sveier, Harald; Migaud, Herve; Helvik, Jon Vidar (Peer reviewed; Journal article, 2022)
      Light cues vary along the axis of periodicity, intensity and spectrum and perception of light is dependent on the photoreceptive capacity encoded within the genome and the opsins expressed. A global approach was taken to ...

    • Pituitary Gonadotropin Gene Expression During Induced Onset of Postsmolt Maturation in Male Atlantic Salmon: In Vivo and Tissue Culture Studies 

      Crespo, Diego; Skaftnesmo, Kai Ove; Kjærner-Semb, Erik Nordtorp; Yilmaz, Ozlem; Norberg, Birgitta; Olausson, Sara; Vogelsang, Petra; Bogerd, Jan; Kleppe, Lene; Edvardsen, Rolf Brudvik; Andersson, Eva; Wargelius, Anna; Hansen, Tom Johnny; Fjelldal, Per Gunnar; Schulz, Rüdiger W. (Peer reviewed; Journal article, 2022)
      Precocious male maturation causes reduced welfare and increased production costs in Atlantic salmon (Salmo salar) aquaculture. The pituitary produces and releases follicle-stimulating hormone (Fsh), the gonadotropin ...

    • The Piwil1 N domain is required for germ cell survival in Atlantic salmon 

      Almeida, Fernanda Loureiro; Skaftnesmo, Kai Ove; Andersson, Eva; Kleppe, Lene; Edvardsen, Rolf Brudvik; Norberg, Birgitta; Fjelldal, Per Gunnar; Hansen, Tom Johnny; Schulz, Rüdiger W.; Wargelius, Anna (Peer reviewed; Journal article, 2022)
      Genetic introgression of farmed salmon into wild populations can damage the genetic integrity of wild stocks and is therefore considered as an environmental threat. One possible solution is to induce sterility in farmed ...

    • Rescue of germ cells in dnd crispant embryos opens the possibility to produce inherited sterility in Atlantic salmon 

      Guralp, Hilal; Skaftnesmo, Kai Ove; Kjærner-Semb, Erik Nordtorp; Straume, Anne Hege; Kleppe, Lene; Schulz, Rüdiger W.; Edvardsen, Rolf Brudvik; Wargelius, Anna (Peer reviewed; Journal article, 2020)
      Genetic introgression of escaped farmed Atlantic salmon (Salmo salar) into wild populations is a major environmental concern for the salmon aquaculture industry. Using sterile fish in commercial aquaculture operations is, ...

    • The salmon louse genome: Copepod features and parasitic adaptations 

      Skern-Mauritzen, Rasmus; Malde, Ketil; Eichner, Christiane; Dondrup, Michael; Furmanek, Tomasz; Besnier, Francois; Komisarczuk, Anna Zofia; Nuhn, Michael; Dalvin, Sussie; Edvardsen, Rolf Brudvik; Klages, Sven; Huettel, Bruno; Stueber, Kurt; Grotmol, Sindre; Karlsbakk, Egil Erlingsson; Kersey, Paul; Leong, Jong S; Glover, Kevin Alan; Reinhardt, Richard; Lien, Sigbjørn; Jonassen, Inge; Koop, Ben F; Nilsen, Frank (Peer reviewed; Journal article, 2021)
      Copepods encompass numerous ecological roles including parasites, detrivores and phytoplankton grazers. Nonetheless, copepod genome assemblies remain scarce. Lepeophtheirus salmonis is an economically and ecologically ...